STX12 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		STX12	DNAJC5
Description		syntaxin 12	DnaJ heat shock protein family (Hsp40) member C5
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GO Annotations	Cellular Component	Golgi Membrane Phagophore Assembly Site Nucleoplasm Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Synaptic Vesicle Membrane BLOC-1 Complex SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Vesicle Membrane Raft Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Postsynaptic Recycling Endosome	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Protein Binding ATP-dependent Protein Binding
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Endocytic Recycling Cholesterol Efflux Vesicle Docking Protein Stabilization Regulation Of Biological Quality	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways			Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		44 interacting genes: AQP6 AQP8 BCL2L13 BLOC1S6 CD79A CISD2 DNAJC5 DTX2 EBP EEA1 EPB42 ERGIC3 FAM209A FCER1G GORAB HOMER1 KASH5 LEPROTL1 LMNA MFSD6 MMGT1 NAPA NEMP1 NSG1 PDZK1IP1 PLPPR2 RIC3 SEC11C SLC10A1 SLC10A6 SLC66A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STXBP5L TIMMDC1 TLCD4 TMEM14B TMEM167B TMEM31 TMEM86B TMX2	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		23673	80331
HPRD ID		06059	08539
Ensembl ID		ENSG00000117758	ENSG00000101152
Uniprot IDs		Q86Y82	Q9H3Z4
PDB IDs		2DNX	2N04 2N05
Enriched GO Terms of Interacting Partners?		Membrane SNARE Complex Exocytosis Membrane Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNAP Receptor Activity Membrane Organization Secretion By Cell Synaptic Vesicle Membrane Organization Synaptic Vesicle Priming Vesicle-mediated Transport Vesicle Fusion Syntaxin Binding Organelle Membrane Fusion Secretion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Docking Synaptic Vesicle Docking Vesicle Organization Vesicle Docking Establishment Of Localization In Cell Organelle Localization SNARE Binding Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Presynaptic Active Zone Membrane Signal Release Bile Acid:sodium Symporter Activity Cellular Localization Synaptic Vesicle Exocytosis Vesicle-mediated Transport In Synapse Mitochondrial Membrane ATP-dependent Protein Binding Regulated Exocytosis Vesicle Docking Involved In Exocytosis Ammonium Channel Activity Cytoplasmic Vesicle Ammonium Transmembrane Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Presynapse Regulation Of Synaptic Vesicle Priming Water Channel Activity Tertiary Granule Membrane Intracellular Transport BLOC-1 Complex Vesicle Targeting Somatodendritic Compartment	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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