KPNA6 and STAT1

Number of citations of the paper that reports this interaction (PMID 16298512)
24

Data Source:
HPRD (in vitro)

		KPNA6	STAT1
Gene Name		karyopherin alpha 6 (importin alpha 7)	signal transducer and activator of transcription 1, 91kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite
	Molecular Function	Protein Transporter Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	NLS-bearing Protein Import Into Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter Maternal Process Involved In Female Pregnancy	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Negative Regulation Of Macrophage Fusion Cellular Response To Interferon-beta Response To Drug Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Renal Tubule Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways			Signaling by PDGF Signaling by FGFR in disease ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Signaling by SCF-KIT Downstream signal transduction Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: ANP32A BRCA1 CDKN1B CREBBP CSE1L FRG1B KEAP1 KPNB1 NOP2 NUP50 RAC1 RELB SKP2 STAT1 STAT3 TAF9 ZNF131	103 interactors: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DOT1L DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 ERBB2 FADD FANCC FGFR3 FGFR4 FLT1 FOS FYN GFAP GNB2L1 GTF2I HADH HLA-B HSF1 HSP90AB1 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBC UBE2I VDR XPO1 ZNF467
Entrez ID		23633	6772
HPRD ID		09465	02777
Ensembl ID		ENSG00000025800	ENSG00000115415
Uniprot IDs		O60684	J3KPM9 P42224
PDB IDs			1BF5 1YVL 2KA6
Enriched GO Terms of Interacting Partners?		Response To Cytokine Viral Process Response To Organic Substance Cellular Response To Cytokine Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Nucleocytoplasmic Transport Macromolecule Biosynthetic Process Nuclear Transport Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Positive Regulation Of Cellular Biosynthetic Process Death Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Growth Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Growth Hormone Stimulus Innate Immune Response Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process Response To Stimulus Cellular Macromolecule Biosynthetic Process	Cellular Response To Organic Substance Response To Organic Substance Defense Response Innate Immune Response Response To Cytokine Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Signaling Response To Stress Regulation Of Immune System Process Cell Communication Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Protein Autophosphorylation Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Regulation Of Signaling Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Viral Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		10q22 12q 14q 14q11 15q11 15q26 22q 22q11 22q12 2p25 2q24 2q37 6p22 arid1a chek2 e2f2 eif3s2 extrauterine hei10 ivl leiomyomatosis leiomyosarcomas map3k7ip1 med12 p23 p33 pdgfb pik3r3 ptch2	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		10q22 12q 14q 14q11 15q11 15q26 22q 22q11 22q12 2p25 2q24 2q37 6p22 arid1a chek2 e2f2 eif3s2 extrauterine hei10 ivl leiomyomatosis leiomyosarcomas map3k7ip1 med12 p23 p33 pdgfb pik3r3 ptch2	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?