KPNA6 and NOP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KPNA6	NOP2
Description		karyopherin subunit alpha 6	NOP2 nucleolar protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity RRNA (cytosine-C5-)-methyltransferase Activity Transferase Activity
	Biological Process	Transcription By RNA Polymerase II Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation RRNA Processing RNA Processing Positive Regulation Of Cell Population Proliferation Methylation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Assembly of the ORC complex at the origin of replication	rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		35 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS DYRK1A EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 OGT POLR3C POM121 POU6F2 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	16 interacting genes: CDC42 CDCA7L CEBPA CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ PVT1 RAB2B RNF10 SUMO2 UBE2I USP7 VPS52
Entrez ID		23633	4839
HPRD ID		09465	01244
Ensembl ID		ENSG00000025800	ENSG00000111641
Uniprot IDs		O60684	P46087
PDB IDs		4UAD 7RHT	8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Stress P53 Binding Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Cytokine Production Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Erythrocyte Differentiation Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Transcription Coactivator Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Erythrocyte Differentiation Regulation Of Programmed Cell Death Transcription Coactivator Binding	Macrophage Differentiation Positive Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization To Nucleolus Myeloid Cell Differentiation SUMO Transferase Activity PML Body Leukocyte Differentiation Mononuclear Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Body Presynaptic Cytosol Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Embryonic Ectodermal Digestive Tract Development SUMO Conjugating Enzyme Activity Positive Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Glutamatergic Synapse Postsynapse Regulation Of Vesicle-mediated Transport Nucleolus Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Regulation Of Endoribonuclease Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Regulation Of Growth Negative Regulation Of Protein Kinase Activity
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