KPNA6 and SKP2

Number of citations of the paper that reports this interaction (PMID 22770219)
12

Data Source:
BioGRID (unspecified method)

		KPNA6	SKP2
Gene Name		karyopherin alpha 6 (importin alpha 7)	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Transporter Activity	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter Maternal Process Involved In Female Pregnancy	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ANP32A BRCA1 CDKN1B CREBBP CSE1L FRG1B KEAP1 KPNB1 NOP2 NUP50 RAC1 RELB SKP2 STAT1 STAT3 TAF9 ZNF131	54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		23633	6502
HPRD ID		09465	03256
Ensembl ID		ENSG00000025800	ENSG00000145604
Uniprot IDs		O60684	Q13309
PDB IDs			1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Response To Cytokine Viral Process Response To Organic Substance Cellular Response To Cytokine Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Nucleocytoplasmic Transport Macromolecule Biosynthetic Process Nuclear Transport Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Positive Regulation Of Cellular Biosynthetic Process Death Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Growth Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Growth Hormone Stimulus Innate Immune Response Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process Response To Stimulus Cellular Macromolecule Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process
Tagcloud ?		10q22 12q 14q 14q11 15q11 15q26 22q 22q11 22q12 2p25 2q24 2q37 6p22 arid1a chek2 e2f2 eif3s2 extrauterine hei10 ivl leiomyomatosis leiomyosarcomas map3k7ip1 med12 p23 p33 pdgfb pik3r3 ptch2	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Difference) ?		10q22 12q 14q 14q11 15q11 15q26 22q 22q11 22q12 2p25 2q24 2q37 6p22 arid1a chek2 e2f2 eif3s2 extrauterine hei10 ivl leiomyomatosis leiomyosarcomas map3k7ip1 med12 p23 p33 pdgfb pik3r3 ptch2	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Intersection) ?