KPNA6 and RELB

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		KPNA6	RELB
Gene Name		karyopherin alpha 6 (importin alpha 7)	v-rel avian reticuloendotheliosis viral oncogene homolog B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol I-kappaB/NF-kappaB Complex
	Molecular Function	Protein Transporter Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter Maternal Process Involved In Female Pregnancy	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Antigen Processing And Presentation Circadian Regulation Of Gene Expression Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Osmotic Stress
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ANP32A BRCA1 CDKN1B CREBBP CSE1L FRG1B KEAP1 KPNB1 NOP2 NUP50 RAC1 RELB SKP2 STAT1 STAT3 TAF9 ZNF131	25 interactors: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11
Entrez ID		23633	5971
HPRD ID		09465	06886
Ensembl ID		ENSG00000025800	ENSG00000104856
Uniprot IDs		O60684	D6R992 Q01201
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Cytokine Viral Process Response To Organic Substance Cellular Response To Cytokine Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Nucleocytoplasmic Transport Macromolecule Biosynthetic Process Nuclear Transport Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Positive Regulation Of Cellular Biosynthetic Process Death Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Growth Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Growth Hormone Stimulus Innate Immune Response Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process Response To Stimulus Cellular Macromolecule Biosynthetic Process	Nucleosome Disassembly Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated ATP-dependent Chromatin Remodeling Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Chromosome Organization Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Metabolic Process Toll-like Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Nucleosome Organization Response To Inorganic Substance Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Chromatin Assembly Or Disassembly Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		10q22 12q 14q 14q11 15q11 15q26 22q 22q11 22q12 2p25 2q24 2q37 6p22 arid1a chek2 e2f2 eif3s2 extrauterine hei10 ivl leiomyomatosis leiomyosarcomas map3k7ip1 med12 p23 p33 pdgfb pik3r3 ptch2	balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify rela s32 s36 serines
Tagcloud (Difference) ?		10q22 12q 14q 14q11 15q11 15q26 22q 22q11 22q12 2p25 2q24 2q37 6p22 arid1a chek2 e2f2 eif3s2 extrauterine hei10 ivl leiomyomatosis leiomyosarcomas map3k7ip1 med12 p23 p33 pdgfb pik3r3 ptch2	balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify rela s32 s36 serines
Tagcloud (Intersection) ?