KPNA6 and IL1A

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		KPNA6	IL1A
Description		karyopherin subunit alpha 6	interleukin 1 alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Transcription By RNA Polymerase II Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Intracellular Sodium Ion Homeostasis Apoptotic Process Response To Stress Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cell Division Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Assembly of the ORC complex at the origin of replication	Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Body mass index ( 26426971)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		35 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS DYRK1A EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 OGT POLR3C POM121 POU6F2 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		23633	3552
HPRD ID		09465	00988
Ensembl ID		ENSG00000025800	ENSG00000115008
Uniprot IDs		O60684	P01583
PDB IDs		4UAD 7RHT	2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Stress P53 Binding Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Cytokine Production Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Erythrocyte Differentiation Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Transcription Coactivator Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Erythrocyte Differentiation Regulation Of Programmed Cell Death Transcription Coactivator Binding	Interleukin-1 Binding Interleukin-1 Receptor Activity Interleukin-1-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Response To Cytokine Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Interleukin-1, Type I, Activating Receptor Activity Interleukin-33 Receptor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Alpha Production Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin AIM2 Inflammasome Complex IPAF Inflammasome Complex Calpain Complex Viral Penetration Into Host Nucleus Mammary Gland Involution Cysteine-type Peptidase Activity Cytokine Precursor Processing Positive Regulation Of Neutrophil Extravasation Somite Specification Granulocyte Colony-stimulating Factor Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Peptide
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