KPNA6 and ANP32A

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		KPNA6	ANP32A
Description		karyopherin subunit alpha 6	acidic nuclear phosphoprotein 32 family member A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Binding Protein Binding Histone Binding
	Biological Process	Transcription By RNA Polymerase II Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Nucleocytoplasmic Transport Intracellular Signal Transduction Regulation Of Apoptotic Process
Pathways		Assembly of the ORC complex at the origin of replication	HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Esophageal cancer ( 21642993)
Interacting Genes		35 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS DYRK1A EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 OGT POLR3C POM121 POU6F2 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	30 interacting genes: ADAP1 APEX1 ATXN1 AXIN1 CHAF1A E4F1 ELAVL1 H2AC20 H2BC21 H3-4 H3C1 H3C15 H4C1 H4C16 HSPB3 KPNA1 KPNA5 KPNA6 LHX3 LINC00632 MAP1B NSFL1C PCBP1 PGR PPARG PTPRC SET TAF1A THRB XPO1
Entrez ID		23633	8125
HPRD ID		09465	09014
Ensembl ID		ENSG00000025800	ENSG00000140350
Uniprot IDs		O60684	A0A384P5U2 P39687
PDB IDs		4UAD 7RHT	2JE0 2JE1 4XOS 6XZQ 8RMR 8RN0 8RNA 8RNB 8RNC
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Stress P53 Binding Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Cytokine Production Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Erythrocyte Differentiation Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Transcription Coactivator Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Erythrocyte Differentiation Regulation Of Programmed Cell Death Transcription Coactivator Binding	Nucleosome Assembly Nucleosome Organization Structural Constituent Of Chromatin Nucleus Protein-DNA Complex Assembly Nucleosome Chromatin Remodeling DNA Binding Chromatin Organization Nuclear Transport Nucleocytoplasmic Transport NLS-dependent Protein Nuclear Import Complex Nucleoplasm Protein Heterodimerization Activity Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Negative Regulation Of Macromolecule Biosynthetic Process NLS-bearing Protein Import Into Nucleus Protein Localization To Organelle Negative Regulation Of Biosynthetic Process Protein Localization To Nucleus Negative Regulation Of RNA Metabolic Process Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Protein-containing Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Protein Import Into Nucleus DNA Replication-dependent Chromatin Assembly Import Into Nucleus Telomere Organization Transcription Coactivator Binding Nuclear Receptor Activity Protein-containing Complex Organization Cellular Component Assembly Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Transcription By RNA Polymerase II Chromosome, Telomeric Region Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin
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