KPNA6 and NMNAT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KPNA6	NMNAT1
Description		karyopherin subunit alpha 6	nicotinamide nucleotide adenylyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Nucleotide Binding Nicotinamide-nucleotide Adenylyltransferase Activity Catalytic Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	Transcription By RNA Polymerase II Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Purine Nucleotide Metabolic Process Nicotinamide Metabolic Process Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Response To Wounding Pyridine Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development ATP Generation From Poly-ADP-D-ribose
Pathways		Assembly of the ORC complex at the origin of replication	Nicotinate metabolism
Drugs			Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Body mass index ( 26426971)	Resting heart rate ( 27798624)
Interacting Genes		35 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS DYRK1A EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 OGT POLR3C POM121 POU6F2 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		23633	64802
HPRD ID		09465	16369
Ensembl ID		ENSG00000025800	ENSG00000173614
Uniprot IDs		O60684	B1AN62 Q9HAN9
PDB IDs		4UAD 7RHT	1GZU 1KKU 1KQN 1KQO 1KR2 8QE8
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Stress P53 Binding Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Cytokine Production Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Erythrocyte Differentiation Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Transcription Coactivator Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Erythrocyte Differentiation Regulation Of Programmed Cell Death Transcription Coactivator Binding	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Localization To Nucleus Intracellular Transport Of Virus Host Cell Protein Import Into Nucleus Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Triglyceride Biosynthetic Process Cellular Localization Intracellular Protein Transport Regulation Of Amyloid Precursor Protein Catabolic Process Intracellular Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Negative Regulation Of Triglyceride Metabolic Process Establishment Of Localization In Cell Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Life Cycle Establishment Of Protein Localization Regulation Of Anoikis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Receptor Internalization Intracellular Protein Localization Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Cellular Response To Nerve Growth Factor Stimulus Protein Transport Viral Process Regulation Of Muscle Cell Differentiation
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