SH3BP1 and ABI2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3BP1	ABI2
Description		SH3 domain binding protein 1	abl interactor 2
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GO Annotations	Cellular Component	Exocyst Phagocytic Cup Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge Cell Projection Anchoring Junction	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Adherens Junction Lamellipodium Filopodium SCAR Complex Filopodium Tip Cell Projection Dendritic Spine Anchoring Junction Actin-based Cell Projection
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding	Protein Binding Cytoskeletal Anchor Activity SH3 Domain Binding Kinase Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Ruffle Assembly	Mitophagy Neuron Migration Cytoskeleton Organization Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Zonula Adherens Assembly Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		RAC1 GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Butyrylcholinesterase levels ( 21862451) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		14 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK POT1 RAC1 RHOA SRC SYNJ1 TERF1 TRIP10	194 interacting genes: ABI3 ABL1 ABLIM3 ACTMAP ADAM19 AIRIM AKAP8L AKAP9 ANKRD55 ANKS1A ARHGAP32 ARMC7 ATOSB ATP23 BAG4 BIN3 BLOC1S5 BLOC1S6 BORCS6 C1orf216 C20orf202 C4orf17 CCDC102B CCDC57 CCDC74B CCHCR1 CDK6 CENPH CENPQ CEP44 CEP57 CIMIP2B CLPP COG3 CRX CUEDC1 DCTN2 DISC1 DLGAP2 DLGAP4 DNAI7 DTNB EFS EGLN3 EGR4 EIF3H ENAH ENKD1 FAM161B FAM90A1 FAM9C FBXL19 FHL5 FKBP1A FOXD4L1 GAS2L2 GCC1 GFAP GGN GPANK1 HGS HHEX HNRNPK HOMER3 HSF2BP IFT20 IHO1 INCA1 INO80B INSYN1 KHDRBS1 KIAA1217 KIFC3 KNSTRN KRT13 KRT14 KRT15 KRT19 KRT20 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT75 LENG1 LGALS9B LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LNX1 LURAP1 LZTS2 MAGEA1 MCM7 MED10 MED11 MED29 MEOX2 MRFAP1 MRFAP1L1 MRPL28 MRPL44 MYO15B MYOG MYOZ3 NCK1 NCK2 NCKIPSD NFASC NME4 NUP62 OGT OIP5 OOEP PAK2 PCM1 PDLIM7 PFDN5 PHETA1 PHF1 PIN1 PLEKHN1 POMC PPIF PPP3CA PRAM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA1 PWWP2B RABEP1 RABGEF1 RASD1 RNPS1 RPP25 RSPH14 RUSC1 SDCBP SH3BP1 SH3KBP1 SHANK3 SLA SMARCB1 SMARCD1 SNAP23 SNAP91 SNAPIN SNX18 SNX7 SORBS3 STAM2 STX19 STX4 TFIP11 TLE5 TPM2 TRAF3IP1 TRIM32 TRIM72 TRIML2 TRIP6 UBQLN2 USHBP1 USP2 VARS2 VASP VCL VMA22 VPS28 VPS37C WASF2 WASF3 WASHC1 WASHC3 WASL WIPF1 WWOX ZFP90 ZMYND12 ZNF474 ZNF688
Entrez ID		23616	10152
HPRD ID		10227	07338
Ensembl ID		ENSG00000100092	ENSG00000138443
Uniprot IDs		A0A2X0SFX7 Q9Y3L3	A0A0C4DG21 A0A7D9NKC8 B7Z836 E9PEZ7 F8WAL6 Q9NYB9
PDB IDs		4J9D 4J9F	2ED0 3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Substrate Adhesion-dependent Cell Spreading Cell Motility Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Neuron Migration Positive Regulation Of Cellular Component Biogenesis Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Podosome Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Migration Positive Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Junction Organization Regulation Of Actin Filament-based Process Cellular Component Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Filament Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein-containing Complex Assembly Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Vasoconstriction Regulation Of Organelle Assembly Actin Filament Organization Regulation Of Cell Junction Assembly Regulation Of Actin Filament Organization Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Negative Regulation Of Telomere Maintenance Regulation Of Synapse Organization	Protein Binding Supramolecular Fiber Organization Organelle Organization Cytoskeleton Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Actin Filament Organization SH3 Domain Binding Cytoskeletal Anchor Activity Plasma Membrane Bounded Cell Projection Assembly Structural Molecule Activity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Cellular Component Assembly Cell Projection Organization Lamellipodium Assembly Epithelial Cell Differentiation Actin Polymerization Or Depolymerization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Postsynaptic Density Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Regulation Of Cytoskeleton Organization Lamellipodium Organization Intermediate Filament Cytoskeleton Actin Cytoskeleton Glutamatergic Synapse Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Translational Initiation Regulation Of Cellular Component Organization Cytoplasm Microtubule-based Process Positive Regulation Of Cytoskeleton Organization Vesicle Organization Positive Regulation Of Cellular Component Biogenesis Protein Localization To Vacuole Intracellular Protein Localization Morphogenesis Of An Epithelium Actin Binding Microvesicle Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Organelle Positive Regulation Of RNA Biosynthetic Process
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