SH3BP1 and CCDC146

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3BP1	CCDC146
Description		SH3 domain binding protein 1	coiled-coil domain containing 146
Image			No pdb structure
GO Annotations	Cellular Component	Exocyst Phagocytic Cup Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge Cell Projection Anchoring Junction	Cytoplasm Centrosome Centriole Cytoskeleton Cilium Axoneme Midbody Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Sperm Head-tail Coupling Apparatus
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Ruffle Assembly	Cell Morphogenesis Nucleus Organization Spermatogenesis Spermatid Development Sperm Axoneme Assembly Single Fertilization Cell Population Proliferation Gene Expression Cell Differentiation Flagellated Sperm Motility Cilium Organization Sperm Flagellum Assembly Manchette Assembly
Pathways		RAC1 GTPase cycle
Drugs
Diseases
GWAS			Amyloid beta positivity ( 34154648) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Macrovascular complications in type 2 diabetes ( 33430853) Ophthalmic complications in type 2 diabetes ( 33430853) Response to amphetamines ( 22952603)
Interacting Genes		14 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK POT1 RAC1 RHOA SRC SYNJ1 TERF1 TRIP10	71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 CFTR DRC4 DTNBP1 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52
Entrez ID		23616	57639
HPRD ID		10227	11150
Ensembl ID		ENSG00000100092	ENSG00000135205
Uniprot IDs		A0A2X0SFX7 Q9Y3L3	Q8IYE0 Q96MS1
PDB IDs		4J9D 4J9F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Substrate Adhesion-dependent Cell Spreading Cell Motility Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Neuron Migration Positive Regulation Of Cellular Component Biogenesis Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Podosome Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Migration Positive Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Junction Organization Regulation Of Actin Filament-based Process Cellular Component Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Filament Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein-containing Complex Assembly Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Vasoconstriction Regulation Of Organelle Assembly Actin Filament Organization Regulation Of Cell Junction Assembly Regulation Of Actin Filament Organization Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Negative Regulation Of Telomere Maintenance Regulation Of Synapse Organization	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Cytoskeleton Structural Molecule Activity Organelle Organization Supramolecular Fiber Organization Epithelial Cell Differentiation Microtubule-based Process Protein Binding Morphogenesis Of An Epithelium Centrosome Cycle Tissue Morphogenesis Microtubule Nucleation Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Microtubule Binding Vesicle Transport Along Microtubule
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