SH3BP1 and SYNJ1

Number of citations of the paper that reports this interaction (PMID 10764144)
7

Data Source:
HPRD (two hybrid, in vivo)

		SH3BP1	SYNJ1
Gene Name		SH3-domain binding protein 1	synaptojanin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Membrane Coat
	Molecular Function	GTPase Activator Activity SH3 Domain Binding	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity
	Biological Process	Signal Transduction Positive Regulation Of GTPase Activity	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Neurotransmitter Transport Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Regulation Of Synaptic Vesicle Membrane Organization Positive Regulation Of Synaptic Vesicle Uncoating
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ABL1 CRK HCK POT1 RAC1 RHOA SRC SYNJ1 TERF1 TRIP10	23 interactors: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2
Entrez ID		23616	8867
HPRD ID		10227	09182
Ensembl ID		ENSG00000100092	ENSG00000159082
Uniprot IDs		Q9Y3L3	B9EGN3 C9JFZ1 J3KPK1 J3KQV8 O43426 Q05CZ1
PDB IDs			1W80 2DNR 2VJ0
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Endocytosis Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Endocytosis Regulation Of Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Actin Filament-based Process Blood Coagulation Hemostasis Peptidyl-tyrosine Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Complex Assembly Immune Response-regulating Signaling Pathway Substrate Adhesion-dependent Cell Spreading Regulation Of DNA Biosynthetic Process Platelet Activation Positive Regulation Of Cytoskeleton Organization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Body Fluid Levels Cellular Component Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Wound Healing Actin Cytoskeleton Organization Regulation Of Podosome Assembly Positive Regulation Of Immune Response Actin Filament-based Process Positive Regulation Of Cell Cycle Cell Activation Response To Wounding Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Regulation Of Protein Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Innate Immune Response	Endocytosis Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Transport Neuron Projection Morphogenesis Cell-cell Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Axonogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neuron Projection Development Regulation Of Cellular Component Organization Axon Development Cell Projection Organization Membrane Organization Synaptic Transmission Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Transport Locomotion Neuron Development Membrane Tubulation Cell Morphogenesis Involved In Differentiation Nervous System Development Cellular Localization Movement Of Cell Or Subcellular Component Neuron Differentiation Establishment Of Localization In Cell Generation Of Neurons Regulation Of Endocytosis Neurogenesis Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization
Tagcloud ?		aggregate bar bargin bgin cin colocalization comprises detergent enact enigmatic gap inactivates inactivating membranous module nox1 poly proteotoxic proteotoxicity rac1 recoding relay rhogap rhogtpase spliced stretch tangle themes ub	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Difference) ?		aggregate bar bargin bgin cin colocalization comprises detergent enact enigmatic gap inactivates inactivating membranous module nox1 poly proteotoxic proteotoxicity rac1 recoding relay rhogap rhogtpase spliced stretch tangle themes ub	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Intersection) ?