SH3BP1 and TRIP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3BP1	TRIP10
Description		SH3 domain binding protein 1	thyroid hormone receptor interactor 10
Image
GO Annotations	Cellular Component	Exocyst Phagocytic Cup Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge Cell Projection Anchoring Junction	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Ruffle Assembly	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization
Pathways		RAC1 GTPase cycle	Clathrin-mediated endocytosis RHOQ GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK POT1 RAC1 RHOA SRC SYNJ1 TERF1 TRIP10	43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B
Entrez ID		23616	9322
HPRD ID		10227	05142
Ensembl ID		ENSG00000100092	ENSG00000125733
Uniprot IDs		A0A2X0SFX7 Q9Y3L3	Q15642 W4VSQ9
PDB IDs		4J9D 4J9F	2CT4 2EFK 2KE4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Substrate Adhesion-dependent Cell Spreading Cell Motility Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Neuron Migration Positive Regulation Of Cellular Component Biogenesis Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Podosome Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Migration Positive Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Junction Organization Regulation Of Actin Filament-based Process Cellular Component Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Filament Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein-containing Complex Assembly Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Vasoconstriction Regulation Of Organelle Assembly Actin Filament Organization Regulation Of Cell Junction Assembly Regulation Of Actin Filament Organization Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Negative Regulation Of Telomere Maintenance Regulation Of Synapse Organization	Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette
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