C5AR2 and SYNGR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		C5AR2	SYNGR2
Description		complement C5a receptor 2	synaptogyrin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell	Lipid Droplet Synaptic Vesicle Membrane Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Synapse Extracellular Exosome
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Protein Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis	Regulated Exocytosis Synaptic Vesicle Membrane Organization
Pathways		Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS			Adenocarcinoma ( 26732429) Lung cancer ( 26732429) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234	9 interacting genes: BDKRB2 C5AR2 CCR4 DRD2 F2RL1 FATE1 GPR35 LTB4R2 SCARA3
Entrez ID		27202	9144
HPRD ID		17072	04891
Ensembl ID		ENSG00000134830	ENSG00000108639
Uniprot IDs		Q9P296	O43760
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex	G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Signaling Pathway Interneuron Migration Arachidonate Secretion Chemokine Receptor Activity Inflammatory Response G-protein Alpha-subunit Binding Negative Regulation Of Insulin Secretion Membrane Negative Regulation Of Peptide Secretion Long-chain Fatty Acid Transport Vasodilation Smooth Muscle Contraction Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Chemotaxis Negative Regulation Of Hormone Secretion Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Biological Quality Locomotion Negative Regulation Of Protein Secretion Cell Migration Chemokine-mediated Signaling Pathway Bradykinin Receptor Activity Fatty Acid Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Proteinase-activated Receptor Activity Regulation Of Interleukin-8 Production Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Leukotriene B4 Receptor Activity Protease Binding Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Cell Motility Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Complement Component C5a Receptor Activity Leukotriene Receptor Activity Renal System Process
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