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C5AR2 and C4A
Number of citations of the paper that reports this interaction (PMID
11773063
)
43
Data Source:
HPRD
(in vitro)
C5AR2
C4A
Gene Name
complement component 5a receptor 2
complement component 4A (Rodgers blood group)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Basal Plasma Membrane
Integral Component Of Membrane
Apical Part Of Cell
Extracellular Region
Plasma Membrane
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
C5a Anaphylatoxin Receptor Activity
Protein Binding
Complement Component C1q Binding
Endopeptidase Inhibitor Activity
Biological Process
Chemotaxis
Inflammatory Response
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Interleukin-6 Secretion
Regulation Of Interleukin-8 Secretion
Inflammatory Response
Complement Activation
Complement Activation, Classical Pathway
Negative Regulation Of Endopeptidase Activity
Regulation Of Complement Activation
Innate Immune Response
Positive Regulation Of Apoptotic Cell Clearance
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Regulation of Complement cascade
Complement cascade
Activation of C3 and C5
Initial triggering of complement
Innate Immune System
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
3 interactors:
C3
C4A
C5AR1
6 interactors:
APC
APOA2
C3AR1
C5AR2
CR1
CST3
Entrez ID
27202
720
HPRD ID
17072
00401
Ensembl ID
ENSG00000134830
ENSG00000244731
Uniprot IDs
Q9P296
P0C0L4
PDB IDs
1HZF
4FXG
4FXK
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Apoptotic Cell Clearance
Regulation Of Apoptotic Cell Clearance
Regulation Of Complement Activation
Inflammatory Response
Positive Regulation Of Phagocytosis
Regulation Of Humoral Immune Response
Positive Regulation Of Immune Response
Regulation Of Phagocytosis
Regulation Of Acute Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Positive Regulation Of Endocytosis
Complement Activation, Classical Pathway
Humoral Immune Response Mediated By Circulating Immunoglobulin
Complement Activation
Complement Component C5a Signaling Pathway
Protein Activation Cascade
Immune Response
Immunoglobulin Mediated Immune Response
Regulation Of Immune System Process
B Cell Mediated Immunity
Regulation Of Endocytosis
Defense Response
Positive Regulation Of Type IIa Hypersensitivity
Humoral Immune Response
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Negative Regulation Of Endopeptidase Activity
Leukocyte Mediated Immunity
Adaptive Immune Response
Negative Regulation Of Peptidase Activity
Regulation Of Inflammatory Response
Positive Regulation Of Activation Of Membrane Attack Complex
Cell Proliferation In Hindbrain
Complement Receptor Mediated Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Vesicle-mediated Transport
Immune System Process
Regulation Of Endopeptidase Activity
Positive Regulation Of Hypersensitivity
Regulation Of Protein Metabolic Process
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Regulation Of Catalytic Activity
Complement Activation, Alternative Pathway
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
MRNA Transcription From RNA Polymerase II Promoter
Complement Receptor Mediated Signaling Pathway
Regulation Of Immune System Process
Defense Response
Response To Stress
Negative Regulation Of Catalytic Activity
Regulation Of Neutrophil Chemotaxis
Regulation Of Neutrophil Migration
Negative Regulation Of Cytokine Secretion
Regulation Of Granulocyte Chemotaxis
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Negative Regulation Of Immune System Process
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Inflammatory Response
Regulation Of Cytokine Production
Positive Regulation Of Serine-type Endopeptidase Activity
Negative Regulation Of Cholesterol Transporter Activity
Negative Regulation Of Collagen Catabolic Process
Negative Regulation Of Elastin Catabolic Process
Negative Regulation Of Blood Vessel Remodeling
Negative Regulation Of Protein Secretion
Regulation Of Cell Migration
Regulation Of Leukocyte Migration
Regulation Of Cell Motility
Negative Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Negative Regulation Of Immune Response
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Regulation Of Cytokine Secretion
Regulation Of Chemotaxis
Negative Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Complement Activation, Alternative Pathway
Regulation Of Cholesterol Transporter Activity
Negative Regulation Of Cholesterol Import
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Regulation Of Protein Localization
Negative Regulation Of Secretion By Cell
Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling
Regulation Of Collagen Catabolic Process
Regulation Of Cholesterol Import
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Secretion
Negative Regulation Of Protein Transport
Regulation Of Immune Response
Regulation Of Behavior
Regulation Of Protein Metabolic Process
Negative Regulation Of Complement Activation, Classical Pathway
Negative Regulation Of Extracellular Matrix Organization
Tagcloud
?
alleles
antitopoisomerase
backgrounds
c4aq0
c4b
c4bq0
carried
complement
contribution
diffuse
dr
drb1
electrophoresis
genetical
genotyping
hla
immunoblotting
immunofixation
japanese
pc
positivity
q0
reflected
scl
scleroderma
ssc
sscp
subgroup
typing
Tagcloud (Difference)
?
alleles
antitopoisomerase
backgrounds
c4aq0
c4b
c4bq0
carried
complement
contribution
diffuse
dr
drb1
electrophoresis
genetical
genotyping
hla
immunoblotting
immunofixation
japanese
pc
positivity
q0
reflected
scl
scleroderma
ssc
sscp
subgroup
typing
Tagcloud (Intersection)
?