C5AR2 and SLC25A11

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		C5AR2	SLC25A11
Description		complement C5a receptor 2	solute carrier family 25 member 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell	Nucleus Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Membrane
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding	RNA Binding Protein Binding Alpha-ketoglutarate Transmembrane Transporter Activity Antiporter Activity Oxoglutarate:malate Antiporter Activity Transmembrane Transporter Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis	Gluconeogenesis Lipid Transport Alpha-ketoglutarate Transport Malate-aspartate Shuttle Transmembrane Transport Malate Transmembrane Transport
Pathways		Peptide ligand-binding receptors Regulation of Complement cascade	Organic anion transport by SLC5/17/25 transporters Malate-aspartate shuttle
Drugs
Diseases
GWAS			Platelet count ( 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252)
Interacting Genes		17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234	5 interacting genes: C5AR2 CDKN1A COPA SLC22A1 WEE2-AS1
Entrez ID		27202	8402
HPRD ID		17072	05003
Ensembl ID		ENSG00000134830	ENSG00000108528
Uniprot IDs		Q9P296	Q02978 Q6IBH0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex	PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cellular Response To Cell-matrix Adhesion Protein Localization To Cell Leading Edge Pancreatic Juice Secretion (R)-carnitine Transmembrane Transport Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity Spermidine Transport Basal Plasma Membrane Metanephric Proximal Tubule Development Epinephrine Transport Norepinephrine:sodium Symporter Activity (R)-carnitine Transport Spermidine Transmembrane Transport Putrescine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity O-acyl-L-carnitine Transmembrane Transport Thiamine Transmembrane Transport Acetylcholine Transmembrane Transporter Activity Complement Component C5a Receptor Activity Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis Pre-mRNA 5'-splice Site Binding Oncogene-induced Cell Senescence Stress-induced Premature Senescence Carnitine Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Proximal Tubule Development Carnitine Transmembrane Transport Polyamine Transmembrane Transport Negative Regulation Of Neutrophil Migration Serotonin Uptake Norepinephrine Transport Complement Receptor Activity MRNA 5'-splice Site Recognition Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein Localization To Axon Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transmembrane Transporter Activity
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