ETHE1 and IGSF21

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ETHE1	IGSF21
Gene Name		ethylmalonic encephalopathy 1	immunoglobin superfamily, member 21
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Extracellular Region
	Molecular Function	Iron Ion Binding Sulfur Dioxygenase Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Glutathione Metabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Hydrogen Sulfide Metabolic Process
Pathways		Sulfide oxidation to sulfate Degradation of cysteine and homocysteine Sulfur amino acid metabolism Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		5 interactors: APP ATP6V1H IGSF21 LRIF1 RELA	32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		23474	84966
HPRD ID		09764	11309
Ensembl ID		ENSG00000105755	ENSG00000117154
Uniprot IDs		B2RCZ7 M0QXB5 O95571	Q96ID5
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Acetaldehyde Metabolic Process Transition Metal Ion Homeostasis Positive Regulation Of Schwann Cell Differentiation Synaptic Growth At Neuromuscular Junction Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Schwann Cell Differentiation Response To Cobalamin Collateral Sprouting Axon Midline Choice Point Recognition Response To Insulin Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of MiRNA Metabolic Process Cellular Response To Peptide Hormone Stimulus Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Axon Choice Point Recognition Cellular Response To Peptide Response To Light Stimulus Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Neuron Remodeling Cellular Metal Ion Homeostasis Regulation Of MiRNA Metabolic Process Response To Oxidative Stress Vacuolar Acidification Cellular Cation Homeostasis Response To Radiation Response To Peptide Hormone Cellular Ion Homeostasis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Organonitrogen Compound Metal Ion Homeostasis Response To Peptide Response To Muramyl Dipeptide Response To UV-B Membrane Protein Intracellular Domain Proteolysis Cellular Chemical Homeostasis Cellular Copper Ion Homeostasis Viral Process Ion Homeostasis Intracellular PH Reduction Cellular Response To Hormone Stimulus PH Reduction Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Defense Response To Virus By Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Interleukin-6	Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth
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