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UPF1
Gene Name
UPF1 regulator of nonsense transcripts homolog (yeast)
Image
Gene Ontology Annotations
Cellular Component
Chromatin
Cytoplasmic MRNA Processing Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Exon-exon Junction Complex
Supraspliceosomal Complex
Molecular Function
DNA Binding
Chromatin Binding
RNA Binding
ATP-dependent RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nuclear-transcribed MRNA Catabolic Process
DNA Replication
DNA Repair
MRNA Export From Nucleus
Regulation Of Translational Termination
Dosage Compensation By Inactivation Of X Chromosome
Gene Expression
Histone MRNA Catabolic Process
Pathways
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-protein Interactions
31 interactors:
ABHD16A
ACSS2
ATR
CSNK2B
DCP1A
DCP2
DXO
EIF3A
EIF3B
EIF4A3
EXOSC2
EXOSC4
GNPTG
GSPT2
HIRA
LSM8
NADSYN1
NDRG1
NDUFB10
PLEKHA5
PLEKHB2
POLR2A
RHOXF2
RPRD2
SMG1
SMG5
STAU1
UPF2
UPF3A
UPF3B
XRN1
Entrez ID
5976
HPRD ID
03254
Ensembl ID
ENSG00000005007
Uniprot IDs
Q92900
PDB IDs
2GJK
2GK6
2GK7
2IYK
2WJV
2WJY
2XZO
2XZP
Enriched GO Terms of Interacting Partners
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Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
Aromatic Compound Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cellular Macromolecule Catabolic Process
RNA Localization
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear MRNA Surveillance
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RNA Surveillance
MRNA Transport
RNA Transport
Gene Expression
Catabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Histone MRNA Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Nuclear Export
Nucleocytoplasmic Transport
Nuclear Transport
Nitrogen Compound Metabolic Process
MRNA Export From Nucleus
RNA Export From Nucleus
Histone MRNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Metabolic Process
Cytoplasmic Transport
Posttranscriptional Regulation Of Gene Expression
Regulation Of Translation
RRNA Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Ribonucleoprotein Complex Biogenesis
Ribosome Biogenesis
Intracellular MRNA Localization
RRNA Catabolic Process
Positive Regulation Of Translation
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Maturation Of 5.8S RRNA
NcRNA Metabolic Process
RNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis
Formation Of Translation Preinitiation Complex
RRNA Processing
Tagcloud
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aav9
adeno
als
amyotrophic
cord
decay
empty
exerts
forelimb
green
helps
implicate
mycupf1
nmd
nonsense
otherwise
paralysis
quadriplegic
recapitulate
reproducible
respective
spinal
tdp
titrated
transactive
twofold
upframeshift
validate
vector