UPF1 and DXO

Number of citations: 47 (PubMedID 15231747)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		UPF1	DXO
Name		UPF1 RNA helicase and ATPase	decapping exoribonuclease
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity Telomeric DNA Binding Protein-containing Complex Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity MRNA 5'-diphosphatase Activity Metal Ion Binding RNA NAD+-cap (NAD+-forming) Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Regulation Of Gene Expression Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Metabolic Process NAD-cap Decapping
Pathways		Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nuclear RNA decay
GWAS		Attention deficit hyperactivity disorder ( 32595297 )	Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Disease progression in age-related macular degeneration ( 29346644 ) Inflammatory bowel disease ( 28067908 ) Ulcerative colitis ( 28067908 )
Interacting Genes		106 interacting genes: ABHD16A ACSS2 ATR CEBPA CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LINC00113 LSM8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A PTEN RHOXF2 RNF10 RPRD2 SMG1 SMG5 STAU1 SUMO2 UPF2 UPF3A UPF3B XRN1	8 interacting genes: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2
Entrez ID		5976	1797
HPRD ID		03254	16186
Ensembl ID		ENSG00000005007	ENSG00000204348
Uniprot IDs		A0A024R7L5 B3KY55 Q92900	A0A024RCW8 A0A1U9X7N5 F8WC68 O77932
PDB IDs		2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5 6Z3R 8RXB	Not available
GO Terms Enriched among Interactors		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Destabilization MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus	Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Nuclear RNA Surveillance Negative Regulation Of Gene Expression RNA Surveillance Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear Exosome (RNase Complex) RRNA Catabolic Process RRNA Metabolic Process Exosome (RNase Complex) Negative Regulation Of Metabolic Process MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Exonuclease Activity Nucleolus SnRNA Metabolic Process RRNA Processing Macromolecule Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Regulation Of Gene Expression RNA 3'-end Processing Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process RRNA 3'-end Processing 5'-3' Exonuclease Activity TRNA Decay RNA Metabolic Process Regulation Of Telomere Maintenance Nuclease Activity RNA Binding Regulation Of Macromolecule Metabolic Process Sno(s)RNA Metabolic Process