UPF1 and DXO

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UPF1	DXO
Gene Name		UPF1 regulator of nonsense transcripts homolog (yeast)	decapping exoribonuclease
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex	Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Binding ATP-dependent RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding	Nucleotide Binding Magnesium Ion Binding MRNA Binding 5'-3' Exonuclease Activity RNA Pyrophosphohydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Gene Expression Histone MRNA Catabolic Process	MRNA Catabolic Process Metabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG GSPT2 HIRA LSM8 NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1	8 interactors: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2
Entrez ID		5976	1797
HPRD ID		03254	16186
Ensembl ID		ENSG00000005007	ENSG00000204348
Uniprot IDs		Q92900	O77932
PDB IDs		2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process RNA Localization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Surveillance MRNA Transport RNA Transport Gene Expression Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Nitrogen Compound Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Metabolic Process Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression Regulation Of Translation RRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Intracellular MRNA Localization RRNA Catabolic Process Positive Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Maturation Of 5.8S RRNA NcRNA Metabolic Process RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Formation Of Translation Preinitiation Complex RRNA Processing	Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Aromatic Compound Catabolic Process RNA Surveillance MRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Dosage Compensation By Inactivation Of X Chromosome Catabolic Process Dosage Compensation RRNA Catabolic Process RNA Metabolic Process RRNA Processing Gene Expression NcRNA Metabolic Process Maturation Of 5.8S RRNA Ribosome Biogenesis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Nitrogen Compound Metabolic Process DNA Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Histone H3-R2 Methylation RNA Localization Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Regulation Of Gene Expression, Epigenetic DNA Deamination Intracellular MRNA Localization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Translational Termination Histone H4-R3 Methylation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation
Tagcloud ?		aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector	1beta bioreactor cd11b cdh5 constructs dataset dioxepan ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?		aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector	1beta bioreactor cd11b cdh5 constructs dataset dioxepan ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?