UPF1 and ABHD16A

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		UPF1	ABHD16A
Gene Name		UPF1 regulator of nonsense transcripts homolog (yeast)	abhydrolase domain containing 16A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex	Integral Component Of Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Binding ATP-dependent RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding	Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Gene Expression Histone MRNA Catabolic Process	Metabolic Process
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG GSPT2 HIRA LSM8 NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1	19 interactors: ATP5G3 DNAJC1 DTX2 FAM134C GPRC5C HM13 HNRNPA1 IFITM1 MLH1 ND3 ND4 PILRB PTGS2 RNF5 SAFB SPAG7 TMEM147 TMEM222 UPF1
Entrez ID		5976	7920
HPRD ID		03254	15929
Ensembl ID		ENSG00000005007	ENSG00000204427
Uniprot IDs		Q92900	B3KNX9 O95870
PDB IDs		2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process RNA Localization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Surveillance MRNA Transport RNA Transport Gene Expression Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Nitrogen Compound Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Metabolic Process Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression Regulation Of Translation RRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Intracellular MRNA Localization RRNA Catabolic Process Positive Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Maturation Of 5.8S RRNA NcRNA Metabolic Process RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Formation Of Translation Preinitiation Complex RRNA Processing	Respiratory Electron Transport Chain Electron Transport Chain ATP Metabolic Process Cellular Respiration Mitochondrial Electron Transport, NADH To Ubiquinone Nucleotide Metabolic Process Purine Nucleoside Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Maintenance Of Blood-brain Barrier Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Ribonucleotide Metabolic Process Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Oxidative Phosphorylation RNA Export From Nucleus Negative Regulation Of Mitotic Recombination ER-associated Misfolded Protein Catabolic Process Positive Regulation Of Fibroblast Growth Factor Production Generation Of Precursor Metabolites And Energy Female Gamete Generation Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Nuclear Export MRNA Transport Posttranscriptional Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Organophosphate Metabolic Process RNA Transport Positive Regulation Of Brown Fat Cell Differentiation Nuclear-transcribed MRNA Catabolic Process RNA Localization Heterocycle Metabolic Process MRNA Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Prostaglandin Biosynthetic Process MRNA Catabolic Process Positive Regulation Of Synaptic Plasticity Spindle Midzone Assembly Positive Regulation Of Sprouting Angiogenesis Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process
Tagcloud ?		aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector	15d abpp bat5 c14 c18 c20 c7600 dag delta12 diacylglycerol ebelactone genuine glycerolipid hbat5 j2 linoleylglycerol lysophospholipase mag mags monoacylglycerols oxadiazol palmostatin pave pgj2 phenoxyphenyl tetrahydrolipstatin triacylglycerol unveiling
Tagcloud (Difference) ?		aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector	15d abpp bat5 c14 c18 c20 c7600 dag delta12 diacylglycerol ebelactone genuine glycerolipid hbat5 j2 linoleylglycerol lysophospholipase mag mags monoacylglycerols oxadiazol palmostatin pave pgj2 phenoxyphenyl tetrahydrolipstatin triacylglycerol unveiling
Tagcloud (Intersection) ?