RHOB and ARHGEF3

Number of citations of the paper that reports this interaction (PubMedID 12221096)
0

Data Source:
HPRD (in vivo)

		RHOB	ARHGEF3
Description		ras homolog family member B	Rho guanine nucleotide exchange factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure	Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle
Drugs		Botulinum toxin type A
Diseases
GWAS		Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 19110211 19820697 32888494 22139419 24026423 31194788 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 22139419 32888494 27863252 29066854 23263863 28031487 26805783 29403010 24026423) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)
Interacting Genes		18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5	9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27
Entrez ID		388	50650
HPRD ID		01321	12480
Ensembl ID		ENSG00000143878	ENSG00000163947
Uniprot IDs		P62745	B7Z6B2 B7Z7T8 C9J586 E9PG37 Q9NR81
PDB IDs		2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation	Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure Regulation Of Modification Of Synaptic Structure Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Nucleation GTPase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Actin Filament Organization Mitotic Cytokinesis Regulation Of Actin Filament Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cleavage Furrow Mitotic Cleavage Furrow Formation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Identical Protein Binding GTP Binding GDP Binding Aortic Valve Formation Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Actin Filament-based Process Skeletal Muscle Satellite Cell Migration Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Epithelial Tube Morphogenesis Beta Selection Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Bone Trabecula Morphogenesis Membrane Curvature Sensor Activity Intracellular Transport Intracellular Protein Transport Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Fibrillar Center Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
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