RHOB and ADORA2A

Data Source: HiPPIP (Novel)

		RHOB	ADORA2A
Name		ras homolog family member B	adenosine A2a receptor
Structure
GO Annotations	Cellular Component	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse	Intermediate Filament Plasma Membrane Membrane Axon Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Presynaptic Active Zone Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Calmodulin Binding Lipid Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure	Synaptic Transmission, Dopaminergic G Protein-coupled Adenosine Receptor Signaling Pathway Response To Amphetamine Regulation Of DNA-templated Transcription Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Purine-containing Compound Response To Caffeine Positive Regulation Of Synaptic Transmission, GABAergic Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Vasodilation Eating Behavior Negative Regulation Of Vascular Permeability Response To Alkaloid Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Alpha-beta T Cell Activation Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle	NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism
Drugs		Botulinum toxin type A	Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline KW-6356
GWAS		Systemic sclerosis ( 21750679 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Acne (severe) ( 24927181 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Coffee consumption (cups per day) ( 31217584 ) Coronary artery disease ( 26343387 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Severity of nausea and vomiting of pregnancy ( 29563502 )
Novel Interactors		2 novel interactors: ADORA2A SNX17	7 novel interactors: CDH2 DDT FZD3 GGT1 GGT5 RHOB SLC35A2
Interacting Genes		18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5	25 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CD4 CHN1 CNR1 CYTH2 DRD2 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 SLC25A39 SLC4A1AP SNCA SPNS1 SYNGR1
Entrez ID		388	135
HPRD ID		01321	00043
Ensembl ID		ENSG00000143878	ENSG00000128271
Uniprot IDs		P62745	A8K1F6 B3KVQ4 P29274 X5DNB4
PDB IDs		2FV8 6HXU 6SGE	2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6LPJ 6LPK 6LPL 6MH8 6PS7 6S0L 6S0Q 6WQA 6ZDR 6ZDV 7ARO 7EZC 7PX4 7PYR 7RM5 7T32 8A2O 8A2P 8C9W 8CIC 8CU6 8CU7 8DU3 8GNE 8GNG 8JWY 8JWZ 8PWN 8RQQ 8RVW 8RW0 8RW4 8RW7 8RWC 8RWD 8RWE 8RWH 8RWI 8RWX 8UGW 8WDT 9FUP
GO Terms Enriched among Interactors		Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation	Pseudopodium Cortical Actin Cytoskeleton Cell Junction Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Synapse Actin Cytoskeleton Plasma Membrane Focal Adhesion Assembly Positive Regulation Of MAPK Cascade Phenol-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of ERK1 And ERK2 Cascade Dopamine Metabolic Process Muscle Cell Development Response To Iron Ion Leukotriene C4 Gamma-glutamyl Transferase Activity Cell-substrate Junction Assembly Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Cell-substrate Junction Organization Presynapse Catecholamine Metabolic Process Glutathione Hydrolase Activity Leukotriene D4 Biosynthetic Process Fascia Adherens Negative Regulation Of Oxidative Phosphorylation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Calcium Ion Binding Transmembrane Transporter Binding Focal Adhesion Z Disc Cell Junction Assembly Negative Regulation Of Cellular Respiration Glutathione Catabolic Process Dopamine Biosynthetic Process Postsynaptic Actin Cytoskeleton Regulation Of Intracellular Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Glutathione Metabolic Process Positive Regulation Of Intracellular Signal Transduction Integrin Binding Sarcomere Cell Junction Organization Response To Inactivity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Neuronal Synaptic Plasticity Catecholamine Uptake