RHOB and RHPN2

Number of citations of the paper that reports this interaction (PubMedID 12473120)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RHOB	RHPN2
Description		ras homolog family member B	rhophilin Rho GTPase binding protein 2
Image
GO Annotations	Cellular Component	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse	Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure	Glomerular Filtration Signal Transduction Negative Regulation Of Stress Fiber Assembly
Pathways		GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle
Drugs		Botulinum toxin type A
Diseases
GWAS		Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 19011631 24737748 24836286 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5	6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1
Entrez ID		388	85415
HPRD ID		01321	10192
Ensembl ID		ENSG00000143878	ENSG00000131941
Uniprot IDs		P62745	Q8IUC4
PDB IDs		2FV8 6HXU 6SGE	2VSV
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation	Apoptotic Process Programmed Cell Death Cell Death Tissue Morphogenesis Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure I-SMAD Binding Regulation Of Modification Of Synaptic Structure Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Regulation Of Programmed Cell Death Negative Regulation Of Chondrocyte Differentiation Tissue Development Negative Regulation Of Cartilage Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Anatomical Structure Formation Involved In Morphogenesis Wnt Signaling Pathway Negative Regulation Of Cell Migration Tube Morphogenesis Positive Regulation Of Stress Fiber Assembly Cell Surface Receptor Signaling Pathway Morphogenesis Of An Epithelium Membrane Invagination Non-canonical Wnt Signaling Pathway Regulation Of Chondrocyte Differentiation SMAD Binding Cleavage Furrow Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of Actin Filament Bundle Assembly Rho Protein Signal Transduction Mitotic Cytokinesis Signal Transduction Cell Differentiation Regulation Of Cartilage Development Regulation Of Developmental Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Regulation Of Cell Size Engulfment Of Target By Autophagosome Endothelial Cell Migration Regulation Of Stem Cell Proliferation Cytoskeleton-dependent Cytokinesis Cell Periphery Regulation Of Stress Fiber Assembly Positive Regulation Of Developmental Process Nuclear Receptor-mediated Signaling Pathway Animal Organ Morphogenesis Cellular Developmental Process
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