RHOB and ARHGDIG

Number of citations of the paper that reports this interaction (PMID 8939998)
18

Data Source:
HPRD (two hybrid)

		RHOB	ARHGDIG
Gene Name		ras homolog family member B	Rho GDP dissociation inhibitor (GDI) gamma
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Late Endosome Membrane Cleavage Furrow Extracellular Vesicular Exosome	Cytosol Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity
	Biological Process	Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Transformed Cell Apoptotic Process Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Endosome To Lysosome Transport Platelet Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Protein Localization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Systemic sclerosis ( 21750679)
Protein-Protein Interactions		9 interactors: ARHGDIG ARHGEF3 CIT FNTA PDE6D PGGT1B PPP2CA RHPN2 TNFAIP1	8 interactors: CDC42 CEP170P1 KXD1 RAC1 RHOA RHOB RHOG RHOH
Entrez ID		388	398
HPRD ID		01321	04163
Ensembl ID		ENSG00000143878	ENSG00000242173
Uniprot IDs		P62745	F1T0H7 Q99819
PDB IDs		2FV8
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Protein Prenylation Regulation Of Catalytic Activity Response To Stimulus Rho Protein Signal Transduction Apoptotic Process Programmed Cell Death Positive Regulation Of Tubulin Deacetylation Cell Death Death Regulation Of Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Regulation Of DNA Replication Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Protein Farnesylation Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Tubulin Deacetylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Deacetylase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Neurotransmitter Receptor Metabolic Process Regulation Of Signaling Ras Protein Signal Transduction Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Mitotic Nuclear Envelope Reassembly Enzyme Linked Receptor Protein Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Heterotrimerization Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Signal Transduction Stress Fiber Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Dendrite Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cell Development Signaling Negative Regulation Of Epithelial To Mesenchymal Transition Cell Communication	Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Hemostasis Axonogenesis Platelet Activation Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Neuron Projection Morphogenesis Cell Activation Response To Wounding Rho Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Intracellular Signal Transduction Cell Projection Morphogenesis Cell Part Morphogenesis Intracellular Signal Transduction Neuron Development Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Morphogenesis Regulation Of Cell Projection Assembly Neuron Differentiation Cell Projection Organization Regulation Of Cell Projection Organization Locomotion Positive Regulation Of Cell Morphogenesis Involved In Differentiation Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament-based Process Movement Of Cell Or Subcellular Component Cell-cell Junction Organization Generation Of Neurons Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Ras Protein Signal Transduction Regulation Of Signaling Neurogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Development Cell Migration Response To External Stimulus Substantia Nigra Development Positive Regulation Of Cell Projection Organization Cell Differentiation
Tagcloud ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Difference) ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Intersection) ?