SRGAP2 and FASLG

Number of citations of the paper that reports this interaction (PubMedID 19807924)
40

Data Source:
BioGRID (unspecified method)

		SRGAP2	FASLG
Description		SLIT-ROBO Rho GTPase activating protein 2	Fas ligand
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Phagocytic Vesicle Glutamatergic Synapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Nervous System Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly Dendritic Spine Development Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Neuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Intracellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Type II Interferon Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 24999842 25920553 20190752) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		6 interacting genes: DISC1 EXOC1 FASLG PCNT ROBO1 YWHAG	82 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK CYSRT1 DAXX DLG2 DMD DNMBP DOCK4 ECM1 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK IHO1 ITK ITSN2 KALRN KMT2A KRT33B KRT40 KRTAP11-1 KRTAP12-3 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SEC23A SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TNS2 TRIP6 YES1
Entrez ID		23380	356
HPRD ID		18520	00610
Ensembl ID		ENSG00000266028	ENSG00000117560
Uniprot IDs		A0A075B7B5 A0A1S5UZH8 B4DFE5 B7Z3G4 B7ZM87 O75044	P48023 Q53ZZ1
PDB IDs		2DL8 4RTT 4RUG 5I6J 5I6R 5I7D	4MSV 5L19 5L36
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipid Translocation Positive Regulation Of Cell Communication Cytoplasmic Vesicle Lumen Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Microtubule Organizing Center Molecular Adaptor Activity Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration TOR Signaling Protein Kinase C Inhibitor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Cellular Component Organization Cytoplasm Regulation Of Plasma Membrane Organization Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Intracellular Signal Transduction Signal Transduction Necroptotic Signaling Pathway Inflammatory Cell Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Intracellular Chloride Ion Homeostasis Endosomal Lumen Acidification Negative Regulation Of Multicellular Organismal Process Necroptotic Process Regulation Of Developmental Process Microtubule Cell Projection Organization Cilium Assembly Plasma Membrane Bounded Cell Projection Organization Cilium Organization LRR Domain Binding Endocardial Cushion Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Heart Induction Positive Regulation Of Neurogenesis Axon Guidance Receptor Activity Axon Choice Point Recognition Positive Regulation Of Nervous System Development	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Organization Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Peptidyl-tyrosine Phosphorylation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Cell Shape Regulation Of Cell Morphogenesis Negative Regulation Of Immune System Process Regulation Of Actin Filament-based Process Positive Regulation Of Immune System Process T Cell Costimulation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Developmental Process Phospholipase Activator Activity Endocytosis B Cell Receptor Signaling Pathway Regulation Of Cell Motility Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Anchoring Junction Positive Regulation Of T Cell Activation
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