SRGAP2

Gene Name		SLIT-ROBO Rho GTPase activating protein 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Cell Junction Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding Rac GTPase Activator Activity Protein Homodimerization Activity Rac GTPase Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Small GTPase Mediated Signal Transduction Axon Guidance Cell Proliferation Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Rac GTPase Activity Substrate Adhesion-dependent Cell Spreading Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration
Pathways		Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor
Drugs
Diseases
GWAS		Cholesterol and Triglycerides ( 23031429)
Protein-protein Interactions		5 interactors: DISC1 EXOC1 FASLG ROBO1 YWHAG
Entrez ID		23380
HPRD ID		18520
Ensembl ID
Uniprot IDs		A2RUF3 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs		2DL8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Neuron Differentiation Cerebral Cortex Cell Migration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Telencephalon Cell Migration Forebrain Cell Migration Zymogen Activation Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neurogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Regulation Of Cell Development Cerebral Cortex Development Roundabout Signaling Pathway Endosomal Lumen Acidification Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Pallium Development Regulation Of Cysteine-type Endopeptidase Activity Retinal Cell Programmed Cell Death Regulation Of Negative Chemotaxis Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Protein Processing Necroptotic Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Axon Choice Point Recognition Mammary Duct Terminal End Bud Growth Positive Regulation Of Signal Transduction Organelle Organization Telencephalon Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Chloride Ion Homeostasis
Tagcloud ?		29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced