SRGAP2

Description		SLIT-ROBO Rho GTPase activating protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Phagocytic Vesicle Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Nervous System Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly Dendritic Spine Development Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Neuron Migration
Pathways		Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)
Interacting Genes		6 interacting genes: DISC1 EXOC1 FASLG PCNT ROBO1 YWHAG
Entrez ID		23380
HPRD ID		18520
Ensembl ID		ENSG00000266028
Uniprot IDs		A0A075B7B5 A0A1S5UZH8 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs		2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipid Translocation Positive Regulation Of Cell Communication Cytoplasmic Vesicle Lumen Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Microtubule Organizing Center Molecular Adaptor Activity Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration TOR Signaling Protein Kinase C Inhibitor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Cellular Component Organization Cytoplasm Regulation Of Plasma Membrane Organization Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Intracellular Signal Transduction Signal Transduction Necroptotic Signaling Pathway Inflammatory Cell Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Intracellular Chloride Ion Homeostasis Endosomal Lumen Acidification Negative Regulation Of Multicellular Organismal Process Necroptotic Process Regulation Of Developmental Process Microtubule Cell Projection Organization Cilium Assembly Plasma Membrane Bounded Cell Projection Organization Cilium Organization LRR Domain Binding Endocardial Cushion Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Heart Induction Positive Regulation Of Neurogenesis Axon Guidance Receptor Activity Axon Choice Point Recognition Positive Regulation Of Nervous System Development
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