SRGAP2 and YWHAG

Number of citations of the paper that reports this interaction (PMID 15324660)
121

Data Source:
HPRD (in vivo)

		SRGAP2	YWHAG
Gene Name		SLIT-ROBO Rho GTPase activating protein 2	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Cell Junction Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle	Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Rac GTPase Activator Activity Protein Homodimerization Activity Rac GTPase Binding	Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Poly(A) RNA Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Small GTPase Mediated Signal Transduction Axon Guidance Cell Proliferation Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Rac GTPase Activity Substrate Adhesion-dependent Cell Spreading Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Protein Targeting Apoptotic Process Organelle Organization Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor	Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Cholesterol and Triglycerides ( 23031429)	Multiple sclerosis ( 21654844)
Protein-Protein Interactions		5 interactors: DISC1 EXOC1 FASLG ROBO1 YWHAG	285 interactors: ABL1 ABLIM1 ACIN1 AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5A1 ATP5B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L2 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FAM53C FAM65B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 HDAC4 HDAC7 HECTD1 HIST1H3A HIVEP2 HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 JAKMIP1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MLLT4 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRPF38B PRPF40A PRPF4B PTPN14 PTPN3 PUF60 RAB11A RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 SSFA2 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UCP2 UCP3 USP37 USP8 WEE1 WNK1 WWTR1 YAP1 YWHAB YWHAE YWHAH YWHAQ ZAK ZBTB21 ZFP36
Entrez ID		23380	7532
HPRD ID		18520	05639
Ensembl ID			ENSG00000170027
Uniprot IDs		A2RUF3 B4DFE5 B7Z3G4 B7ZM87 O75044	P61981
PDB IDs		2DL8	2B05 3UZD 4E2E 4J6S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Neuron Differentiation Cerebral Cortex Cell Migration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Telencephalon Cell Migration Forebrain Cell Migration Zymogen Activation Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neurogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Regulation Of Cell Development Cerebral Cortex Development Roundabout Signaling Pathway Endosomal Lumen Acidification Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Pallium Development Regulation Of Cysteine-type Endopeptidase Activity Retinal Cell Programmed Cell Death Regulation Of Negative Chemotaxis Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Protein Processing Necroptotic Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Axon Choice Point Recognition Mammary Duct Terminal End Bud Growth Positive Regulation Of Signal Transduction Organelle Organization Telencephalon Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Chloride Ion Homeostasis	Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Cell Death Apoptotic Process Programmed Cell Death Death Cellular Component Assembly RNA Splicing Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process MRNA Metabolic Process MRNA Processing Neurotrophin Signaling Pathway Cell Cycle Regulation Of Signaling Cellular Process Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Cellular Localization RNA Processing Mitotic Cell Cycle Process Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Fc Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Organic Substance Cell Cycle Process Cellular Response To Organic Substance Establishment Of Localization In Cell System Development Regulation Of Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Developmental Process MRNA Splicing, Via Spliceosome Regulation Of Organelle Organization Cell Communication RNA Splicing, Via Transesterification Reactions Cellular Response To Stimulus Signaling Response To Stimulus
Tagcloud ?		29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced	7q11 atypical autism autistic baz1b beuren carry centromeric deletions epilepsy excludes flanking fzd9 haploinsufficiency hemizygous hip1 huntingtin mb monooxigenase monooxygenase multisystemic neuropsychological preservation shed spanning svas tryptophan wbs williams
Tagcloud (Difference) ?		29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced	7q11 atypical autism autistic baz1b beuren carry centromeric deletions epilepsy excludes flanking fzd9 haploinsufficiency hemizygous hip1 huntingtin mb monooxigenase monooxygenase multisystemic neuropsychological preservation shed spanning svas tryptophan wbs williams
Tagcloud (Intersection) ?