SRGAP2 and EXOC1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		SRGAP2	EXOC1
Description		SLIT-ROBO Rho GTPase activating protein 2	exocyst complex component 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Phagocytic Vesicle Glutamatergic Synapse	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Nervous System Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly Dendritic Spine Development Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Neuron Migration	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Defense Response To Virus Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)	Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Urinary albumin excretion ( 32277301) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: DISC1 EXOC1 FASLG PCNT ROBO1 YWHAG	29 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST ITSN1 KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNCA SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIO
Entrez ID		23380	55763
HPRD ID		18520	07615
Ensembl ID		ENSG00000266028	ENSG00000090989
Uniprot IDs		A0A075B7B5 A0A1S5UZH8 B4DFE5 B7Z3G4 B7ZM87 O75044	Q9NV70
PDB IDs		2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipid Translocation Positive Regulation Of Cell Communication Cytoplasmic Vesicle Lumen Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Microtubule Organizing Center Molecular Adaptor Activity Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration TOR Signaling Protein Kinase C Inhibitor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Cellular Component Organization Cytoplasm Regulation Of Plasma Membrane Organization Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Intracellular Signal Transduction Signal Transduction Necroptotic Signaling Pathway Inflammatory Cell Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Intracellular Chloride Ion Homeostasis Endosomal Lumen Acidification Negative Regulation Of Multicellular Organismal Process Necroptotic Process Regulation Of Developmental Process Microtubule Cell Projection Organization Cilium Assembly Plasma Membrane Bounded Cell Projection Organization Cilium Organization LRR Domain Binding Endocardial Cushion Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Heart Induction Positive Regulation Of Neurogenesis Axon Guidance Receptor Activity Axon Choice Point Recognition Positive Regulation Of Nervous System Development	Microtubule Binding Microtubule-based Process Cytoskeleton Organelle Organization Phosphatidylinositol 3-kinase Inhibitor Activity Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Cellular Localization Cell Leading Edge Cell Projection Cytoskeleton Organization Positive Regulation Of Cell Size Regulation Of Cytoskeleton Organization Microtubule Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cell Projection Organization Actin Binding Cytoplasmic Vesicle Positive Regulation Of Cellular Component Organization Guanyl-nucleotide Exchange Factor Activity Intracellular Transport Regulation Of Organelle Organization Phagophore Assembly Site Membrane Establishment Of Localization In Cell Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Synapse Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Negative Regulation Of Protein-containing Complex Assembly Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule-based Process Negative Regulation Of Cellular Component Organization Phagophore Assembly Site Ribophagy Protein-membrane Adaptor Activity Extrinsic Component Of Phagophore Assembly Site Membrane Positive Regulation Of Neuroblast Proliferation Lamellipodium Assembly Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Lamellipodium Assembly Involved In Ameboidal Cell Migration Regulation Of Endocytosis Positive Regulation Of Axon Extension
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?