SRGAP2 and EXOC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		SRGAP2	EXOC1
Gene Name		SLIT-ROBO Rho GTPase activating protein 2	exocyst complex component 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Cell Junction Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle	Exocyst Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Rac GTPase Activator Activity Protein Homodimerization Activity Rac GTPase Binding	Protein Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Small GTPase Mediated Signal Transduction Axon Guidance Cell Proliferation Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Rac GTPase Activity Substrate Adhesion-dependent Cell Spreading Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration	Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization
Pathways		Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor	Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS		Cholesterol and Triglycerides ( 23031429)	Cervical cancer ( 23817570)
Protein-Protein Interactions		5 interactors: DISC1 EXOC1 FASLG ROBO1 YWHAG	28 interactors: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST GOLGA4 KANSL1 KDM1A KIAA0226 KIAA1551 KIF5A LUC7L2 MACF1 NUF2 RALA RB1CC1 SFR1 SH3BP5 SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIM9 TRIO
Entrez ID		23380	55763
HPRD ID		18520	07615
Ensembl ID			ENSG00000090989
Uniprot IDs		A2RUF3 B4DFE5 B7Z3G4 B7ZM87 O75044	Q9NV70
PDB IDs		2DL8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Neuron Differentiation Cerebral Cortex Cell Migration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Telencephalon Cell Migration Forebrain Cell Migration Zymogen Activation Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neurogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Regulation Of Cell Development Cerebral Cortex Development Roundabout Signaling Pathway Endosomal Lumen Acidification Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Pallium Development Regulation Of Cysteine-type Endopeptidase Activity Retinal Cell Programmed Cell Death Regulation Of Negative Chemotaxis Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Protein Processing Necroptotic Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Axon Choice Point Recognition Mammary Duct Terminal End Bud Growth Positive Regulation Of Signal Transduction Organelle Organization Telencephalon Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Chloride Ion Homeostasis	Golgi To Plasma Membrane Transport Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Organization Locomotion Nervous System Development Post-Golgi Vesicle-mediated Transport Microtubule-based Process Regulation Of Cell Projection Organization Generation Of Neurons Regulation Of Autophagy TOR Signaling Organelle Organization Golgi To Plasma Membrane Protein Transport Neurogenesis Regulation Of Cell Size Regulation Of Cellular Component Size Chemotaxis Intracellular Signal Transduction Cellular Component Assembly Regulation Of Neuron Projection Development Vesicle-mediated Transport Autophagy Cellular Localization Axon Guidance Regulation Of Neurogenesis Positive Regulation Of Axon Extension Autophagic Vacuole Assembly Establishment Of Localization In Cell Regulation Of Primitive Erythrocyte Differentiation Lamellipodium Assembly Involved In Ameboidal Cell Migration Lamellipodium Assembly Microtubule Cytoskeleton Organization Cell Projection Organization Cell Communication Lamellipodium Organization Positive Regulation Of Neural Precursor Cell Proliferation Macroautophagy Cell Projection Morphogenesis Regulation Of Cell Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of SNARE Complex Assembly Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Axonogenesis Regulation Of Axon Extension Regulation Of Neuron Differentiation Regulation Of Organelle Organization Cell Cycle Response To External Stimulus Golgi Vesicle Transport
Tagcloud ?		29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced
Tagcloud (Difference) ?		29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced
Tagcloud (Intersection) ?