TNS2 and CRKL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TNS2	CRKL
Gene Name		tensin 2	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Kidney Development Negative Regulation Of Cell Proliferation Response To Muscle Activity Dephosphorylation Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Intracellular Signal Transduction Multicellular Organismal Homeostasis	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways			Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AXL BRCA1 C11orf87 C19orf66 CRKL CSNK1E ERBB2 ERBB3 FGFR1 GFI1B ITGB3 ITGB5 ITGB7 KIF1A KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 NUBP2 PKP1 REEP6 REL TBC1D16 TEKT5 ZNF250 ZNF417 ZNF587	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		23371	1399
HPRD ID		16256	03596
Ensembl ID		ENSG00000111077	ENSG00000099942
Uniprot IDs		Q63HR2	P46109
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Immune System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cell-substrate Adhesion Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Histone H3-K4 Methylation Integrin-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase III Promoter Heterotypic Cell-cell Adhesion Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Process Phosphatidylinositol-mediated Signaling Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Innate Immune Response Cell Surface Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Multicellular Organismal Development Intracellular Signal Transduction Cellular Response To Organic Substance Viral Entry Into Host Cell Positive Regulation Of Phosphorylation Response To Organic Substance	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?			actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?			actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?