FBXW11 and NFKBIA

Number of citations: 0 (PubMedID 10644755)
Data Source: HPRD (in vitro, in vivo)

		FBXW11	NFKBIA
Name		F-box and WD repeat domain containing 11	NFKB inhibitor alpha
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule SCF Ubiquitin Ligase Complex Neuron Projection Neuronal Cell Body Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex
	Molecular Function	Protein Binding Protein Dimerization Activity Microtubule Plus-end Binding Dynein Complex Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Protein Polyubiquitination Protein Dephosphorylation Nuclear Migration Germ Cell Development Retrograde Axonal Transport Wnt Signaling Pathway Protein Ubiquitination Microtubule Organizing Center Organization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Positive Regulation Of Circadian Rhythm Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Vesicle Transport Along Microtubule Rhythmic Process Brain Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Notch Signaling Pathway Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Signal Transduction Involved In Regulation Of Gene Expression Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cholesterol Transport Response To Muramyl Dipeptide Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response B Cell Receptor Signaling Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Activation of NF-kappaB in B cells Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation SARS-CoV-1 activates/modulates innate immune responses Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		None	Acetylsalicylic acid Bardoxolone methyl Astaxanthin
Diseases		None	Hodgkin lymphoma Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS		Appendicular lean mass ( 33097823 ) Height ( 20881960 23563607 25282103 25429064 28552196 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172 )	Appendicular lean mass ( 33097823 ) Asthma ( 32296059 30929738 ) Asthma (childhood onset) ( 30929738 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Creatine kinase levels ( 29403010 ) Eczema ( 31361310 ) Hip circumference adjusted for BMI ( 25673412 ) Inflammatory skin disease ( 25574825 ) Lymphocyte count ( 32888494 27863252 ) PR interval ( 32439900 ) Psoriasis ( 20953190 25903422 25854761 25574825 23143594 20953189 ) Psoriasis vulgaris ( 26626624 ) Pulse pressure ( 30578418 27841878 ) Rheumatoid arthritis ( 32723749 ) Systolic blood pressure ( 28739976 27841878 30578418 ) White blood cell count ( 32888494 )
Interacting Genes		29 interacting genes: AGTR1 BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 MITF NFE2L2 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR PTEN RIPK4 TBC1D4 TFE3 TRIM21 UBE2D3 WEE1 ZNF281	92 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 UBE2M UBE2S USP39 VCP ZNF212
Entrez ID		23291	4792
HPRD ID		07294	01235
Ensembl ID		ENSG00000072803	ENSG00000100906
Uniprot IDs		B4DH70 E5RGC1 Q9UKB1	P25963
PDB IDs		6WNX	1IKN 1NFI 6TTU 6Y1J
GO Terms Enriched among Interactors		Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Response To Peptide Negative Regulation Of Metabolic Process Response To Cytokine Regulation Of Autophagy Positive Regulation Of Autophagy Nucleus Signal Transduction Intracellular Signaling Cassette Protein Modification Process Nucleoplasm Intracellular Signal Transduction Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Rhythmic Process Cellular Response To Cytokine Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process I-kappaB/NF-kappaB Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Proteasomal Protein Catabolic Process TOR Signaling Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macrophage Derived Foam Cell Differentiation Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Proteolysis	Regulation Of Canonical NF-kappaB Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Cytosol Nucleus Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process ATP Binding Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Modification-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Intracellular Signaling Cassette Negative Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Protein Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process