FBXW11 and WEE1

Number of citations of the paper that reports this interaction (PubMedID 15070733)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		FBXW11	WEE1
Description		F-box and WD repeat domain containing 11	WEE1 G2 checkpoint kinase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule SCF Ubiquitin Ligase Complex Neuron Projection Neuronal Cell Body Axon Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Protein Dimerization Activity Microtubule Plus-end Binding Dynein Complex Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Protein Polyubiquitination Protein Dephosphorylation Nuclear Migration Germ Cell Development Retrograde Axonal Transport Wnt Signaling Pathway Protein Ubiquitination Microtubule Organizing Center Organization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Positive Regulation Of Circadian Rhythm Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Vesicle Transport Along Microtubule Rhythmic Process Brain Morphogenesis	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Cell Polarity Positive Regulation Of DNA Replication Neuron Projection Morphogenesis Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Activation of NF-kappaB in B cells Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins	Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Factors involved in megakaryocyte development and platelet production
Drugs			9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide MK-1775 Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 20881960 23563607 25282103 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172)	Cutaneous squamous cell carcinoma ( 32041948) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Platelet distribution width ( 32888494)
Interacting Genes		29 interacting genes: AGTR1 BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 MITF NFE2L2 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR PTEN RIPK4 TBC1D4 TFE3 TRIM21 UBE2D3 WEE1 ZNF281	27 interacting genes: AKT1 BRD8 BRSK1 BRSK2 BTRC CASP3 CCNA1 CCNB1 CDC14A CDCA3 CDK1 CDK2 CRK CSNK2A1 EPS15 ERRFI1 FBXW11 MAILR NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAZ
Entrez ID		23291	7465
HPRD ID		07294	01907
Ensembl ID		ENSG00000072803	ENSG00000166483
Uniprot IDs		B4DH70 E5RGC1 Q9UKB1	P30291 Q86V29
PDB IDs		6WNX	1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA 7N3U 8BJU 8WDK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Response To Peptide Negative Regulation Of Metabolic Process Response To Cytokine Regulation Of Autophagy Positive Regulation Of Autophagy Nucleus Signal Transduction Intracellular Signaling Cassette Protein Modification Process Nucleoplasm Intracellular Signal Transduction Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Rhythmic Process Cellular Response To Cytokine Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process I-kappaB/NF-kappaB Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Proteasomal Protein Catabolic Process TOR Signaling Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macrophage Derived Foam Cell Differentiation Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Proteolysis	Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphoserine Residue Binding Protein Modification Process Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Regulation Of Protein Stability Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cytosol Protein Metabolic Process Organelle Organization Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Cellular Response To Stress Protein Targeting SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Signaling Cell Cycle G1/S Phase Transition Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Cytoplasm Microtubule Cytoskeleton Organization Cell Division Protein Kinase Binding Protein Localization To Organelle Response To Stress DNA Damage Checkpoint Signaling Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidyl-serine Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Protein Localization Regulation Of Mitotic Cell Cycle Protein Phosphorylation
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