FBXW11

Gene Name		F-box and WD repeat domain containing 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Activation of NF-kappaB in B cells G2/M Transition Class I MHC mediated antigen processing & presentation Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Adaptive Immune System
Drugs
Diseases
GWAS		Height ( 20881960 23563607)
Protein-protein Interactions		14 interactors: AMER1 BHLHE40 BTRC CDC25A CUL1 GLI2 IFNAR1 KDR NFKB1 NFKBIA PRLR TRIM21 UBE2D3 WEE1
Entrez ID		23291
HPRD ID		07294
Ensembl ID		ENSG00000072803
Uniprot IDs		B4DH70 Q9UKB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Stimulus Regulation Of Type I Interferon Production Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Monoubiquitination Response To Organic Substance Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Cell Cycle Phase Transition Response To Abiotic Stimulus Mammary Gland Epithelium Development Signaling Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Biosynthetic Process Innate Immune Response Regulation Of Cellular Process Activation Of Innate Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Immune System Process Protein Destabilization G1/S Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Mammary Gland Development Protein Polyubiquitination Circadian Rhythm Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Innate Immune Response
Tagcloud ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation