GRAMD4 and GADD45G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRAMD4	GADD45G
Description		GRAM domain containing 4	growth arrest and DNA damage inducible gamma
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Apoptotic Process	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade
Pathways
Drugs
Diseases
GWAS		Urate levels in obese individuals ( 25811787)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 26561523 28107422) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32154731 32203549)
Interacting Genes		13 interacting genes: APP CATSPERT CCDC146 EXOC8 FAM9B GADD45G MTMR9 NTAQ1 PLEKHF2 RBL2 SH2D4A SMARCD1 TACC2	74 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDK11A CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLAGL2 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763
Entrez ID		23151	10912
HPRD ID		11107	05383
Ensembl ID		ENSG00000075240	ENSG00000130222
Uniprot IDs		Q6IC98	O95257
PDB IDs			2WAL 3FFM
Enriched GO Terms of Interacting Partners?			Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Regulation Of MiRNA Transcription Protein Binding Regulation Of MiRNA Metabolic Process Nuclear Steroid Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin B1-CDK1 Complex PCNA-p21 Complex Peroxisome Proliferator Activated Receptor Signaling Pathway Microtubule Cytoskeleton Organization Involved In Mitosis RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Gene Expression Sequence-specific DNA Binding Cyclin-dependent Protein Kinase Holoenzyme Complex Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport DNA Binding Domain Binding Negative Regulation Of Lipid Storage Regulation Of Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centrosome Rhythmic Process Response To Estradiol Retinoic Acid Receptor Signaling Pathway Regulation Of Circadian Rhythm Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Molecular Function Activator Activity Positive Regulation Of Lipoprotein Transport Establishment Of Organelle Localization Organelle Localization Chromatin Negative Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regeneration Positive Regulation Of Chromosome Segregation
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