GADD45G and PDIA4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GADD45G	PDIA4
Gene Name		growth arrest and DNA-damage-inducible, gamma	protein disulfide isomerase family A, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cell Surface Melanosome
	Molecular Function	Protein Binding	Protein Disulfide Isomerase Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPKK Activity Negative Regulation Of Protein Kinase Activity Apoptotic Process Response To Stress Multicellular Organismal Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	Protein Folding Protein Secretion Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Chaperone-mediated Protein Folding
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Height ( 20881960)
Protein-Protein Interactions		55 interactors: AFAP1L1 APP ARPC5L CCNB1 CDK1 CDKN1A CEP57L1 CRIP2 DDAH2 EEF1A1 EEF1G EIF3G ESR1 EZH2 GADD45B GADD45GIP1 GDF9 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RBM48 RDH13 REL RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579	3 interactors: APOB BCL2L1 GADD45G
Entrez ID		10912	9601
HPRD ID		05383	06501
Ensembl ID		ENSG00000130222	ENSG00000155660
Uniprot IDs		O95257 Q5VZ87	P13667
PDB IDs		2WAL 3FFM	3IDV
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Differentiation Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Fibroblast Proliferation Response To Organic Cyclic Compound Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Cellular Response To Stress Cellular Response To Lipid Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Biosynthetic Process Regulation Of Catalytic Activity RNA Biosynthetic Process Regulation Of Kinase Activity Regulation Of Growth Response To Steroid Hormone Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction	Apoptotic Process In Bone Marrow Cellular Response To Acid Chemical Fertilization Response To Virus Suppression By Virus Of Host Apoptotic Process Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Response To Selenium Ion Activation Of MAPKKK Activity Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Very-low-density Lipoprotein Particle Assembly Response To Radiation Triglyceride Mobilization Spermatogenesis Male Gamete Generation In Utero Embryonic Development Low-density Lipoprotein Particle Remodeling Cellular Response To Virus Modulation By Virus Of Host Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of P38MAPK Cascade Negative Regulation Of Anoikis Positive Regulation Of Cell Death Cellular Response To Gamma Radiation Hepatocyte Apoptotic Process Lipoprotein Catabolic Process Protein-lipid Complex Assembly Gamete Generation Endocytosis Positive Regulation Of Cholesterol Storage Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Cellular Response To Prostaglandin Stimulus Lipoprotein Transport Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Response To Cytokine Response To Other Organism Mitochondrion Morphogenesis Modulation By Virus Of Host Morphology Or Physiology Low-density Lipoprotein Particle Clearance Response To Biotic Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Execution Phase Of Apoptosis Response To Stress Chordate Embryonic Development
Tagcloud ?		arrest checkpoints contribute damage direct effectors encodes implicated injury kinases mapk members mitogen numerous often p38 prominent proteins repair roles signals stress ubiquitously upstream variety vivo	calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia3 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Difference) ?		arrest checkpoints contribute damage direct effectors encodes implicated injury kinases mapk members mitogen numerous often p38 prominent proteins repair roles signals stress ubiquitously upstream variety vivo	calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia3 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Intersection) ?