GADD45G and ARPC5L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		GADD45G	ARPC5L
Description		growth arrest and DNA damage inducible gamma	actin related protein 2/3 complex subunit 5 like
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Cortical Cytoskeleton Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade	Cell Migration Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 26561523 28107422) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32154731 32203549)
Interacting Genes		74 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDK11A CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLAGL2 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763	3 interacting genes: ARPC4 GADD45G SHANK3
Entrez ID		10912	81873
HPRD ID		05383	12490
Ensembl ID		ENSG00000130222	ENSG00000136950
Uniprot IDs		O95257	A0A024R897 B3KPC7 Q9BPX5
PDB IDs		2WAL 3FFM	6YW6 8P94
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Regulation Of MiRNA Transcription Protein Binding Regulation Of MiRNA Metabolic Process Nuclear Steroid Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin B1-CDK1 Complex PCNA-p21 Complex Peroxisome Proliferator Activated Receptor Signaling Pathway Microtubule Cytoskeleton Organization Involved In Mitosis RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Gene Expression Sequence-specific DNA Binding Cyclin-dependent Protein Kinase Holoenzyme Complex Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport DNA Binding Domain Binding Negative Regulation Of Lipid Storage Regulation Of Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centrosome Rhythmic Process Response To Estradiol Retinoic Acid Receptor Signaling Pathway Regulation Of Circadian Rhythm Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Molecular Function Activator Activity Positive Regulation Of Lipoprotein Transport Establishment Of Organelle Localization Organelle Localization Chromatin Negative Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regeneration Positive Regulation Of Chromosome Segregation	Actin Binding Arp2/3 Protein Complex Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Observational Learning Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Glutamate Receptor Signaling Pathway GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Specialization Assembly Neurotransmitter-gated Ion Channel Clustering Auditory Behavior Regulation Of Long-term Synaptic Depression Mechanosensory Behavior Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Morphogenesis Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Positive Regulation Of Long-term Synaptic Potentiation Actin Nucleation Positive Regulation Of P38MAPK Cascade Postsynaptic Specialization Organization Regulation Of Long-term Neuronal Synaptic Plasticity Actin Filament Polymerization Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Binding Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Organization Cell Volume Homeostasis Negative Regulation Of Actin Filament Bundle Assembly Forebrain Neuron Differentiation Positive Regulation Of Dendritic Spine Development Regulation Of P38MAPK Cascade Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Regulation Of Dendritic Spine Morphogenesis Postsynapse Organization Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Receptor Clustering
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