GADD45G and PTPRK

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid)

		GADD45G	PTPRK
Gene Name		growth arrest and DNA-damage-inducible, gamma	protein tyrosine phosphatase, receptor type, K
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Photoreceptor Outer Segment Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Integral Component Of Membrane Axon Dendrite Leading Edge Membrane Neuronal Cell Body
	Molecular Function	Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Gamma-catenin Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPKK Activity Negative Regulation Of Protein Kinase Activity Apoptotic Process Response To Stress Multicellular Organismal Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Celiac disease ( 20190752) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		55 interactors: AFAP1L1 APP ARPC5L CCNB1 CDK1 CDKN1A CEP57L1 CRIP2 DDAH2 EEF1A1 EEF1G EIF3G ESR1 EZH2 GADD45B GADD45GIP1 GDF9 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RBM48 RDH13 REL RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579	8 interactors: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM TK1
Entrez ID		10912	5796
HPRD ID		05383	03968
Ensembl ID		ENSG00000130222	ENSG00000152894
Uniprot IDs		O95257 Q5VZ87	B4DHC3 B7ZMG0 Q15262 Q59EZ1 Q5TG12 Q86WJ2
PDB IDs		2WAL 3FFM	2C7S
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Differentiation Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Fibroblast Proliferation Response To Organic Cyclic Compound Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Cellular Response To Stress Cellular Response To Lipid Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Biosynthetic Process Regulation Of Catalytic Activity RNA Biosynthetic Process Regulation Of Kinase Activity Regulation Of Growth Response To Steroid Hormone Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Signal Transduction Cellular Response To Indole-3-methanol Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Protein Modification Process Response To External Stimulus Endothelial Tube Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Protein Complex Assembly Regulation Of P38MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Fate Specification Positive Regulation Of Protein Metabolic Process Response To Mechanical Stimulus Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Fate Commitment Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Adherens Junction Assembly Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Transferase Activity Regulation Of Signaling Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Cellular Component Assembly Centrosome Cycle Apoptotic Process Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Response To Stimulus Developmental Process Cell Death Cellular Response To Mechanical Stimulus Death Regulation Of Protein Metabolic Process Protein Oligomerization Adherens Junction Organization Positive Regulation Of MAPK Cascade Fetal Process Involved In Parturition Negative Regulation Of Cell Cycle Endothelium Development Signal Transduction In Response To DNA Damage Locomotion Centrosome Organization Regulation Of Phosphorylation Regulation Of Endothelial Cell Migration
Tagcloud ?		arrest checkpoints contribute damage direct effectors encodes implicated injury kinases mapk members mitogen numerous often p38 prominent proteins repair roles signals stress ubiquitously upstream variety vivo	activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jag1 jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby
Tagcloud (Difference) ?		arrest checkpoints contribute damage direct effectors encodes implicated injury kinases mapk members mitogen numerous often p38 prominent proteins repair roles signals stress ubiquitously upstream variety vivo	activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jag1 jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby
Tagcloud (Intersection) ?