GRAMD4 and MTMR9

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GRAMD4	MTMR9
Name		GRAM domain containing 4	myotubularin related protein 9
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Binding Enzyme Regulator Activity
	Biological Process	Apoptotic Process Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Apoptotic Process	Endocytosis Negative Regulation Of Autophagy Positive Regulation Of Phosphatase Activity Phosphatidylinositol Dephosphorylation Protein Stabilization Regulation Of Phosphatidylinositol Dephosphorylation
Pathways		None	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol
GWAS		Urate levels in obese individuals ( 25811787 )	Adventurousness ( 30643258 ) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463 ) Brain morphology (MOSTest) ( 32665545 ) Essential hypertension (time to event) ( 32589924 ) Extraversion ( 27918536 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) General factor of neuroticism ( 30867560 ) Processed meat consumption ( 32066663 ) Refractive error ( 32231278 ) Retinal vascular caliber ( 21060863 ) Systemic lupus erythematosus ( 26316170 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: PKDREJ	1 novel interactors: BLK
Interacting Genes		13 interacting genes: APP CATSPERT CCDC146 EXOC8 FAM9B GADD45G MTMR9 NTAQ1 PLEKHF2 RBL2 SH2D4A SMARCD1 TACC2	26 interacting genes: AATK DEPDC5 EMILIN1 ERBB3 ERBB4 EWSR1 FAM169A GRAMD4 INCA1 KDM1A KIAA1328 KRT27 LNX1 MEI4 MOS MTMR6 MTMR7 MTMR8 NECAB2 NMI PTK7 PTPN3 ROR2 SPG21 VAC14 ZNF655
Entrez ID		23151	66036
HPRD ID		11107	09377
Ensembl ID		ENSG00000075240	ENSG00000104643
Uniprot IDs		Q6IC98	Q96QG7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Protein Tyrosine Kinase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Neuregulin Receptor Activity Phosphatidylinositol Dephosphorylation Protein Kinase Activity Phospholipid Dephosphorylation Phosphatidylinositol Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Kinase Activity Developmental Maturation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Establishment Of Planar Polarity Protein Tyrosine Phosphatase Activity Phosphatidylinositol Biosynthetic Process Glycerophospholipid Metabolic Process Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Dephosphorylation Neuron Maturation Glycerolipid Metabolic Process Protein Binding Establishment Of Planar Polarity Involved In Nephron Morphogenesis Lipid Modification PAS Complex Phospholipid Metabolic Process Cell Maturation