GRAMD4 and TACC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRAMD4	TACC2
Description		GRAM domain containing 4	transforming acidic coiled-coil containing protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Protein Binding	Nuclear Receptor Binding
	Biological Process	Apoptotic Process Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Apoptotic Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Nuclear Migration Cerebral Cortex Development
Pathways
Drugs
Diseases
GWAS		Urate levels in obese individuals ( 25811787)	Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Hepcidin/ferritin ratio ( 27846281) Metabolite risk score for predicting weight gain ( 31560688) Myopia (pathological) ( 23049088) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Obesity-related traits ( 23251661) Opioid dependence ( 31250797) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Total body bone mineral density ( 29304378)
Interacting Genes		13 interacting genes: APP CATSPERT CCDC146 EXOC8 FAM9B GADD45G MTMR9 NTAQ1 PLEKHF2 RBL2 SH2D4A SMARCD1 TACC2	18 interacting genes: AURKC BORCS6 CLK2 CLVS2 CREBBP EP300 FMR1 FXR1 GRAMD4 HMG20B KAT2A KAT2B PPP1CC RXRB SMARCA2 SMARCB1 TGM1 YEATS4
Entrez ID		23151	10579
HPRD ID		11107	05600
Ensembl ID		ENSG00000075240	ENSG00000138162
Uniprot IDs		Q6IC98	B2RWP4 B7ZMJ9 D6RAA5 E7EMZ9 E9PBC6 O95359 Q4VXL4 Q4VXL8
PDB IDs
Enriched GO Terms of Interacting Partners?			Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Protein Acetylation Chromatin Organization Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Regulation Of DNA Repair Internal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Gluconeogenesis Transcription Coactivator Activity Acyltransferase Activity Regulation Of Cellular Response To Stress Negative Regulation Of Gluconeogenesis Histone H3K27 Acetyltransferase Activity Histone H3K9 Acetyltransferase Activity Positive Regulation Of Cell Differentiation Regulation Of Glucose Metabolic Process Positive Regulation Of Double-strand Break Repair Chromatin Remodeling Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Developmental Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Cell Development Regulation Of Multicellular Organismal Development Negative Regulation Of Small Molecule Metabolic Process Chromatin Binding Regulation Of DNA Metabolic Process RNA Strand Annealing Activity Positive Regulation Of DNA Repair Regulation Of Cell Development Protein Modification Process Regulation Of Double-strand Break Repair L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Nervous System Development Transcription Initiation-coupled Chromatin Remodeling Intracellular Membraneless Organelle Negative Regulation Of Centriole Replication Gluconeogenesis Kinetochore Positive Regulation Of Gene Expression, Epigenetic Hexose Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of RNA Splicing
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