KIF1B and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 10198040)
50

Data Source:
HPRD (in vivo, in vitro)

		KIF1B	GIPC1
Description		kinesin family member 1B	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytoskeleton Kinesin Complex Microtubule Membrane Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Presynapse Postsynapse Axon Cytoplasm	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding
	Biological Process	Apoptotic Process Microtubule-based Movement Neuron-neuron Synaptic Transmission Neuromuscular Synaptic Transmission Transport Along Microtubule Vesicle-mediated Transport Mitochondrion Transport Along Microtubule Anterograde Synaptic Vesicle Transport Apoptotic Process Involved In Development Retrograde Neuronal Dense Core Vesicle Transport	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hepatitis B virus-related hepatocellular carcinoma ( 29246937) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Lateral orbital frontal cortex volume ( 31530798) Mean platelet volume ( 27863252 22139419 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 18997785) Neutrophil count ( 32888494) Platelet count ( 32888494) Virologic severity in Herpes simplex virus type 2 infection ( 29535370) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)
Interacting Genes		25 interacting genes: ARHGAP1 BRCA1 CALM1 CHP1 CLIP4 CPEB1 DLG1 DLG2 DLG3 DLG4 DSCR4 DYSF EEF1A1 GIPC1 LAMTOR5 PATJ PGM1 PKNOX1 POMP RSPH1 SIAH1 SNTA1 STARD13 TRIM55 YWHAG	37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408
Entrez ID		23095	10755
HPRD ID		05818	05462
Ensembl ID		ENSG00000054523	ENSG00000123159
Uniprot IDs		O60333	A8K2I7 O14908
PDB IDs		2EH0
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Kinase Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Cytoplasm Protein Localization To Cell Junction Postsynaptic Density Membrane Regulation Of Sodium Ion Transmembrane Transport Protein Kinase Binding Cytosol GMP Kinase Activity Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Regulation Of Sodium Ion Transport Cytoplasmic Microtubule Organization Synaptic Signaling GDP Metabolic Process Juxtaparanode Region Of Axon Adherens Junction Cellular Response To Potassium Ion Voltage-gated Potassium Channel Complex Ribonucleoside Diphosphate Metabolic Process Regulation Of Synaptic Plasticity Nucleoside Diphosphate Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Response To Potassium Ion Postsynaptic Density Regulation Of Cell Communication Regulation Of Signaling Regulation Of Monoatomic Cation Transmembrane Transport Sarcolemma Protein K6-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission GMP Metabolic Process AMPA Glutamate Receptor Complex Intracellular Signal Transduction Bicellular Tight Junction Regulation Of Monoatomic Ion Transmembrane Transport	Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility
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