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FOXO1 and PAK1
Number of citations of the paper that reports this interaction (PubMedID
10358014
)
0
Data Source:
HPRD
(in vivo)
FOXO1
PAK1
Description
forkhead box O1
p21 (RAC1) activated kinase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Ruffle
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Membrane
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Cell Projection
Anchoring Junction
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Nucleic Acid Binding
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
Protein Phosphatase 2A Binding
Promoter-specific Chromatin Binding
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Small GTPase Binding
Identical Protein Binding
Gamma-tubulin Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Temperature Homeostasis
Intracellular Glucose Homeostasis
Gluconeogenesis
Regulation Of Gluconeogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Protein Acetylation
Autophagy
Apoptotic Process
DNA Damage Response
Insulin Receptor Signaling Pathway
Cellular Response To Starvation
Gene Expression
Positive Regulation Of Autophagy
Cell Differentiation
Response To Insulin
Cellular Response To Insulin Stimulus
Negative Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Cellular Response To Oxidative Stress
Regulation Of Cell Population Proliferation
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Secretion
Canonical Wnt Signaling Pathway
Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Response To Fatty Acid
Cellular Response To Hyperoxia
Cellular Response To Nitric Oxide
Negative Regulation Of Canonical Wnt Signaling Pathway
Energy Homeostasis
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Regulation Of Neural Precursor Cell Proliferation
Regulation Of Reactive Oxygen Species Metabolic Process
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Exocytosis
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Regulation Of MAPK Cascade
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Microtubule Nucleation
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Actin Filament Organization
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
AKT phosphorylates targets in the nucleus
Regulation of gene expression in beta cells
AKT-mediated inactivation of FOXO1A
Constitutive Signaling by AKT1 E17K in Cancer
MAPK6/MAPK4 signaling
Interleukin-4 and Interleukin-13 signaling
Regulation of localization of FOXO transcription factors
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Fostamatinib
Diseases
Alveolar rhabdomyosarcoma
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Arterial stiffness (
31070453
)
Arterial stiffness index (
31235810
)
Central corneal thickness (
32528159
29760442
20485516
31798171
20719862
)
Corneal hysteresis (
32716492
31246245
30894546
)
Corneal resistance factor (
32716492
31246245
30894546
)
Corneal structure (
23291589
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Heel bone mineral density (
30598549
)
High light scatter reticulocyte count (
32888494
)
Intraocular pressure (
29617998
29235454
)
Mean corpuscular hemoglobin (
32888494
29403010
27863252
)
Mean corpuscular volume (
27863252
32888494
29403010
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
31649266
30194396
)
Weight (
28552196
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Interacting Genes
39 interacting genes:
AKT1
AR
CDK1
CEBPB
CREBBP
CSNK1G1
CTNNB1
DACH1
DANCR
DYRK1A
ESR1
FHL2
FOXG1
G6PC1
GSK3B
HNF4A
HOXA10
HOXA5
LRPPRC
MDM2
MST1
NCOA1
NEDD4L
PAK1
PARP1
PIK3R3
PITX1
PPARG
RARA
SET
SFN
SIRT1
SMAD3
SMAD4
SRC
THRB
TNS2
YWHAG
YWHAZ
89 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BCL6
BMPR1B
BMX
BRSK1
BTG3
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DSCR9
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
KEAP1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
Entrez ID
2308
5058
HPRD ID
00645
03995
Ensembl ID
ENSG00000150907
ENSG00000149269
Uniprot IDs
Q12778
B3KNX7
E9PM17
Q13153
PDB IDs
3CO6
3CO7
3COA
4LG0
5DUI
6LBI
6QVW
6QZR
6QZS
8A62
8A65
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
7VTO
8X5Z
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Response To Hormone
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Binding
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Cellular Response To Oxygen-containing Compound
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Cellular Response To Hormone Stimulus
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Cell Differentiation
Animal Organ Development
Regulation Of Protein Localization
Chromatin
Transcription Regulator Complex
Developmental Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Developmental Process
Transcription Coactivator Binding
Negative Regulation Of Apoptotic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Negative Regulation Of Programmed Cell Death
Enzyme Binding
Positive Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Cell Differentiation
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Signal Transduction
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Developmental Process
Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Supramolecular Fiber Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Component Organization
Protein Phosphorylation
ERBB Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Locomotion
Focal Adhesion
Regulation Of Cell Differentiation
Regulation Of Intracellular Signal Transduction
Lamellipodium
Phosphorylation
Regulation Of Anatomical Structure Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Motility
Protein Kinase Binding
Regulation Of Locomotion
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Motility
Positive Regulation Of Cell Migration
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cell Migration
Developmental Process
Regulation Of Cytoskeleton Organization
Positive Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Protein Localization
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Tagcloud (Difference)
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Tagcloud (Intersection)
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