SERPINB6 and KLK2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
41

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SERPINB6	KLK2
Description		serpin family B member 6	kallikrein related peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Sensory Perception Of Sound Cellular Response To Osmotic Stress	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Neutrophil degranulation Dissolution of Fibrin Clot	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Drotrecogin alfa
Diseases
GWAS		Chronic lymphocytic leukemia ( 26956414) Crohn's disease ( 32581322)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		8 interacting genes: F10 F2 KLK2 MYCBP2 PLAU PLG PROC SUMO2	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		5269	3817
HPRD ID		01413	01006
Ensembl ID		ENSG00000124570	ENSG00000167751
Uniprot IDs		A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237	A0A024R4J4 B4DU77 P20151
PDB IDs			4NFE 4NFF
Enriched GO Terms of Interacting Partners?		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Coagulation Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Peptidase Activity Negative Regulation Of Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Protein Metabolic Process Regulation Of Response To Wounding Proteolysis Positive Regulation Of Wound Healing Endopeptidase Activity Extracellular Space Golgi Lumen External Side Of Plasma Membrane Hydrolase Activity Macromolecule Metabolic Process Protein Processing Extracellular Region Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Biological Quality Endoplasmic Reticulum Lumen Protein Maturation Regulation Of Proteolysis Regulation Of Locomotion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Multicellular Organismal Process Blood Microparticle Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Receptor Ligand Activity Positive Regulation Of Cell Migration Negative Regulation Of Proteolysis Thrombospondin Receptor Activity Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell-matrix Adhesion Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Extracellular Space Extracellular Exosome Extracellular Region Platelet Alpha Granule Lumen Extracellular Matrix Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Blood Microparticle Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Endopeptidase Inhibitor Activity Negative Regulation Of Plasminogen Activation Regulation Of Proteolysis Signaling Receptor Binding Positive Regulation Of Endopeptidase Activity Antibacterial Humoral Response Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Coagulation Platelet Alpha Granule Fibrinolysis Sperm Capacitation Defense Response To Bacterium Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Maturation Molecular Function Activator Activity Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Positive Regulation Of Chemotaxis Positive Regulation Of Coagulation Cell Maturation Regulation Of G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Heparin Binding Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Bacterium Epithelial Cell Morphogenesis Positive Regulation Of Supramolecular Fiber Organization
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