UBE2J2 and TRIM25

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2J2	TRIM25
Gene Name		ubiquitin-conjugating enzyme E2, J2	tripartite motif containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding
	Biological Process	Protein Polyubiquitination Response To Unfolded Protein ER-associated Ubiquitin-dependent Protein Catabolic Process	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		11 interactors: ATP13A2 HERC4 ITCH MGRN1 NEDD4L RNF10 TRIM25 UBC UBE2G2 WWP2 XIAP	27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24
Entrez ID		118424	7706
HPRD ID		15600	02711
Ensembl ID		ENSG00000160087	ENSG00000121060
Uniprot IDs		A6NGS0 Q8N2K1	Q14258
PDB IDs		2F4W
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Negative Regulation Of Type I Interferon Production Viral Life Cycle Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Type I Interferon Production Proteolysis Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Negative Regulation Of Cytokine Production Positive Regulation Of Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Protein Monoubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Regulation Of Innate Immune Response Entry Into Host Cell Protein Autoubiquitination Regulation Of Potassium Ion Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Protein Linear Polyubiquitination Positive Regulation Of Caveolin-mediated Endocytosis Interaction With Host Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance
Tagcloud ?		abolished alter conjugating degradation disrupt ectopic enzyme er inactivated incubation localization mammalian pharmacological proteasomal proteasome regulating second state steady transfected truncated ubc ubcs ubiquitin ubiquitination unfolded unstable upr	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Difference) ?		abolished alter conjugating degradation disrupt ectopic enzyme er inactivated incubation localization mammalian pharmacological proteasomal proteasome regulating second state transfected truncated ubc ubcs ubiquitination unfolded unstable upr	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round tripartite ub ubiquitylates ubiquitylation uncovers vital
Tagcloud (Intersection) ?		steady ubiquitin