TNK2 and MCF2

Number of citations of the paper that reports this interaction (PMID 10652228)
10

Data Source:
HPRD (in vitro, in vivo)

		TNK2	MCF2
Gene Name		tyrosine kinase, non-receptor, 2	MCF.2 cell line derived transforming sequence
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex	Cytosol Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis	Small GTPase Mediated Signal Transduction Dendrite Development Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs		Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	9 interactors: CDC42 GNA13 GNAI2 GNB1 HSP90AA1 RHOA RHOG STUB1 TNK2
Entrez ID		10188	4168
HPRD ID		06104	02406
Ensembl ID		ENSG00000061938	ENSG00000101977
Uniprot IDs		B3KXJ4 C9J1X3 Q07912	B2R9S6 P10911
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Small GTPase Mediated Signal Transduction Response To Stress Response To Wounding Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Signal Transduction Cell Activation Signaling Cell Communication Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Response To External Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cellular Component Organization Axonogenesis Positive Regulation Of Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Substantia Nigra Development Cell Morphogenesis Involved In Differentiation Regulation Of Cell Proliferation Positive Regulation Of Cytokinesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Neuron Projection Development Regulation Of Signal Transduction Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Neural Nucleus Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell Part Morphogenesis
Tagcloud ?		ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein	antigenic bage dbl eso exploit fibrous gage gca gcas germ histiocytoma knew lage liposarcoma mage monophasic msp myxoid ny oligonucleotide prame proto round sarcoma ssx ssx2 sts synovial testis
Tagcloud (Difference) ?		ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein	antigenic bage dbl eso exploit fibrous gage gca gcas germ histiocytoma knew lage liposarcoma mage monophasic msp myxoid ny oligonucleotide prame proto round sarcoma ssx ssx2 sts synovial testis
Tagcloud (Intersection) ?