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TNK2 and SH2D1A
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
TNK2
SH2D1A
Description
tyrosine kinase non receptor 2
SH2 domain containing 1A
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Adherens Junction
Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Anchoring Junction
Grb2-EGFR Complex
Cytoophidium
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
GTPase Inhibitor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Protein Serine Kinase Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Biological Process
Endocytosis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Phosphorylation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Clathrin-dependent Endocytosis
Adaptive Immune Response
Immune System Process
Humoral Immune Response
Cellular Defense Response
Cell-cell Signaling
Natural Killer Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Innate Immune Response
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Immune Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Signaling by LTK
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
ATP
Debromohymenialdisine
Entrectinib
Fostamatinib
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Asthma (
31959851
)
Bronchopulmonary dysplasia (
23897914
)
Low density lipoprotein cholesterol levels (
30498476
)
Total cholesterol levels (
30498476
)
Interacting Genes
52 interacting genes:
AKT1
AQP1
AR
ARSL
ATP5F1A
BAG3
CDC42
CLTC
CSPG4
CTTN
CYSRT1
DPH2
EGFR
FGFR1
FYN
GALT
GRB2
HCK
HECW1
HSH2D
HSP90AB2P
ITFG2
KCNA5
KRTAP10-3
MAGI3
MCF2
MERTK
NCK1
NEK6
NOTCH2NLA
NPHP1
PDGFRB
PIK3R1
PIK3R3
RASGEF1C
RASGRF1
RPL18A
SEZ6
SH2D1A
SH2D1B
SIAH1
SMURF1
SNX9
SOCS4
SRC
SRSF5
UBC
VTI1B
WAS
WWOX
WWP2
YES1
32 interacting genes:
AR
ARHGEF6
ARHGEF7
ATF3
CCDC74A
CD84
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FYB1
FYN
GRB2
KIT
LCK
LETMD1
LHX3
LHX4
LY9
MAPK11
MAPK14
MET
NCK1
NGEF
OLIG1
PTK2
SLAMF1
SLAMF6
SLAMF7
TNK2
ZNHIT1
Entrez ID
10188
4068
HPRD ID
06104
02390
Ensembl ID
ENSG00000061938
ENSG00000183918
Uniprot IDs
A0A499FJ16
A0A5F9ZGX5
A0A5F9ZHJ2
A0A5F9ZHP4
A0A5F9ZI29
B3KXJ4
C9J1X3
Q07912
O60880
PDB IDs
1CF4
1U46
1U4D
1U54
3EQP
3EQR
4EWH
4HZR
4HZS
4ID7
5ZXB
6VQM
7KP6
8FE9
8FZ3
8HMT
8Q5P
8THA
1D1Z
1D4T
1D4W
1KA6
1KA7
1M27
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cytosol
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Cell-cell Junction
Ephrin Receptor Binding
Signal Transduction
Cell Migration
Cell Motility
Regulation Of Cell Projection Organization
Intracellular Signal Transduction
Regulation Of Signal Transduction
Leukocyte Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
T Cell Costimulation
Actin Filament
Phosphotyrosine Residue Binding
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Actin Filament Polymerization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Peptidyl-tyrosine Phosphorylation
Cell Activation
Regulation Of Apoptotic Process
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Localization To Membrane
Regulation Of Programmed Cell Death
Regulation Of Actin Cytoskeleton Organization
Fc Receptor Mediated Stimulatory Signaling Pathway
Response To Platelet-derived Growth Factor
Lymphocyte Activation
Negative Regulation Of Apoptotic Process
Regulation Of Actin Filament Organization
Positive Regulation Of Locomotion
Regulation Of Protein Localization To Plasma Membrane
Plasma Membrane
Protein Autophosphorylation
Cell Differentiation
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Filament-based Process
Regulation Of Biological Quality
Protein Kinase Activity
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Locomotion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Lymphocyte Activation
Positive Regulation Of Metabolic Process
Cell Activation
Protein Kinase Activity
T Cell Activation
Cell Surface Receptor Signaling Pathway
Cellular Developmental Process
Leukocyte Activation
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Cell Differentiation
Regulation Of Immune System Process
ERBB Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Gene Expression
Regulation Of Programmed Cell Death
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Protein Phosphatase Binding
Regulation Of Multicellular Organismal Process
Intracellular Signaling Cassette
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Ephrin Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
ERBB2 Signaling Pathway
Positive Regulation Of MAPK Cascade
Basal Plasma Membrane
Ephrin Receptor Binding
Regulation Of Metabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Immune System Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Lamellipodium Assembly
Animal Organ Development
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Apoptotic Process
SH2 Domain Binding
Adaptive Immune Response
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Tagcloud (Intersection)
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