TNK2 and SEZ6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TNK2	SEZ6
Description		tyrosine kinase non receptor 2	seizure related 6 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Grb2-EGFR Complex Cytoophidium	Endoplasmic Reticulum Plasma Membrane Membrane Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Apical Dendrite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Endocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis	Adult Locomotory Behavior Cerebellar Purkinje Cell Layer Development Regulation Of Dendrite Development Synapse Maturation Excitatory Postsynaptic Potential
Pathways		Signaling by LTK
Drugs		ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases
GWAS		Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)	Language functional connectivity ( 34929384) Mean arterial pressure ( 27618448)
Interacting Genes		52 interacting genes: AKT1 AQP1 AR ARSL ATP5F1A BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R1 PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 UBC VTI1B WAS WWOX WWP2 YES1	3 interacting genes: CHDH TNK2 UBQLN2
Entrez ID		10188	124925
HPRD ID		06104	18041
Ensembl ID		ENSG00000061938	ENSG00000063015
Uniprot IDs		A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 A0A5F9ZHP4 A0A5F9ZI29 B3KXJ4 C9J1X3 Q07912	Q53EL9
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM 7KP6 8FE9 8FZ3 8HMT 8Q5P 8THA
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell-cell Junction Ephrin Receptor Binding Signal Transduction Cell Migration Cell Motility Regulation Of Cell Projection Organization Intracellular Signal Transduction Regulation Of Signal Transduction Leukocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization T Cell Costimulation Actin Filament Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Cell Activation Regulation Of Apoptotic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Lymphocyte Activation Negative Regulation Of Apoptotic Process Regulation Of Actin Filament Organization Positive Regulation Of Locomotion Regulation Of Protein Localization To Plasma Membrane Plasma Membrane Protein Autophosphorylation Cell Differentiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Biological Quality Protein Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Locomotion	Regulation Of Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Grb2-EGFR Complex Negative Regulation Of G Protein-coupled Receptor Internalization Glycine Betaine Biosynthetic Process From Choline Choline Dehydrogenase Activity Cytoophidium Negative Regulation Of Clathrin-dependent Endocytosis Oxidoreductase Activity, Acting On CH-OH Group Of Donors Choline Catabolic Process Regulation Of Endocytosis Choline Metabolic Process GTPase Inhibitor Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Amino-acid Betaine Metabolic Process WW Domain Binding Regulation Of ERAD Pathway Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Receptor-mediated Endocytosis Epidermal Growth Factor Receptor Binding Positive Regulation Of Protein Metabolic Process Cytoplasmic Vesicle Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Autophagosome Assembly Molecular Condensate Scaffold Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Vacuole Organization Flavin Adenine Dinucleotide Binding
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