USP40 and AHSA1

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	AHSA1
Description		ubiquitin specific peptidase 40	activator of HSP90 ATPase activity 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	ATPase Activator Activity Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Protein Folding Positive Regulation Of ATP-dependent Activity Maintenance Of Unfolded Protein
Pathways
Drugs
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	12 interacting genes: AKT1 APP CEBPA CLCN1 EGFR FILNC1 FKBP4 GCH1 HSP90AA1 OGT PTGES3 USP40
Entrez ID		55230	10598
HPRD ID		07166	09768
Ensembl ID		ENSG00000085982	ENSG00000100591
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	G3V438 O95433
PDB IDs			1X53 7DMD 7DME
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	Protein-containing Complex Regulation Of Protein Catabolic Process Reactive Nitrogen Species Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Homodimerization Activity Positive Regulation Of Proteolysis Nitric-oxide Synthase Regulator Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Response To UV-A Positive Regulation Of DNA Metabolic Process Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Biological Quality Regulation Of Proteolysis Response To Tumor Necrosis Factor Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Biosynthetic Process Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Axonal Growth Cone RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Nucleus Regulation Of Peptidyl-serine Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Regulation Of Protein Localization To Membrane Positive Regulation Of Defense Response Positive Regulation Of Protein Localization Cellular Response To Metal Ion Regulation Of Superoxide Metabolic Process System Process Nervous System Process Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Regulation Of Protein Localization Regulation Of Protein Metabolic Process
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