USP40 and APOM

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	APOM
Description		ubiquitin specific peptidase 40	apolipoprotein M
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Extracellular Region Extracellular Space Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Lipid Transporter Activity Phospholipid Binding Antioxidant Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Lipid Transport Cholesterol Efflux High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Negative Regulation Of Plasma Lipoprotein Oxidation Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Oxidant Detoxification
Pathways			Retinoid metabolism and transport
Drugs
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma ( 19836008) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Rheumatoid arthritis ( 21844665) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	3 interacting genes: HGH1 KLF6 USP40
Entrez ID		55230	55937
HPRD ID		07166	06068
Ensembl ID		ENSG00000085982	ENSG00000204444
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	A0A1U9X793 O95445
PDB IDs			2WEW 2WEX 2YG2
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome
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