USP40 and EPB41L1

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	EPB41L1
Description		ubiquitin specific peptidase 40	erythrocyte membrane protein band 4.1 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Actin Binding Structural Molecule Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways			Trafficking of AMPA receptors Neurexins and neuroligins Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)	Basal cell carcinoma ( 33549134) Height ( 23563607) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	20 interacting genes: AGAP2 APP ARHGAP1 CHRM5 DRD2 DRD3 GRIA1 GRIA4 HSPB1 ITPR1 NR3C1 NUMA1 POT1 SRPK2 STARD13 TERF1 USP40 YWHAB YWHAQ YWHAZ
Entrez ID		55230	2036
HPRD ID		07166	04193
Ensembl ID		ENSG00000085982	ENSG00000088367
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	A0A0C4DH22 B7Z653 Q9H4G0
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	Trans-synaptic Signaling Chemical Synaptic Transmission Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Protein Domain Specific Binding Synapse Response To Morphine Regulation Of Neurotransmitter Uptake Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Associative Learning Intracellular Signaling Cassette Negative Regulation Of Protein Localization Regulation Of Protein Localization Signal Transduction Acid Secretion Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Signaling Ionotropic Glutamate Receptor Signaling Pathway Cell Communication Intracellular Signal Transduction Dendrite Negative Regulation Of Synaptic Transmission Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein-containing Complex Response To Cocaine Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Involved In Locomotory Behavior AMPA Glutamate Receptor Activity Synaptic Transmission, Glutamatergic Shelterin Complex Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Dendritic Spine Glutamate Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Learning Positive Regulation Of Cell Cycle Regulation Of Transport Visual Learning Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Visual Behavior
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