USP40 and ALDOB

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	ALDOB
Description		ubiquitin specific peptidase 40	aldolase, fructose-bisphosphate B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Centriolar Satellite Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity Identical Protein Binding ATPase Binding Molecular Adaptor Activity Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Fructose Metabolic Process Fructose Catabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly Negative Regulation Of Pentose-phosphate Shunt
Pathways			Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs			1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases			Hereditary fructose intolerance; Fructosemia
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)	Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33339817 33547301)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	22 interacting genes: AGXT2 APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2 USP40
Entrez ID		55230	229
HPRD ID		07166	01972
Ensembl ID		ENSG00000085982	ENSG00000136872
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	P05062
PDB IDs			1QO5 1XDL 1XDM 8D44
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	Regulation Of Protein Localization To Nucleus Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Chiasma Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Import Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Homeostatic Process Mismatch Repair Complex Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Mesendoderm Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Glycolytic Process Signaling Receptor Activator Activity Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Negative Regulation Of Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Epithelial Cell Proliferation Cellular Response To Stress Apoptotic Process Regulation Of Growth Regulation Of Carbohydrate Catabolic Process Cytosol Mismatched DNA Binding Regulation Of Protein Stability Regulation Of Protein Localization Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Regulation Of ATP Metabolic Process Enzyme Binding Regulation Of MiRNA Transcription Negative Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Reproductive Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Cell Differentiation
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