USP40 and TRAPPC8

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	TRAPPC8
Description		ubiquitin specific peptidase 40	trafficking protein particle complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Golgi Apparatus Cytosol TRAPP Complex TRAPPIII Protein Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport Collagen Biosynthetic Process COPII Vesicle Coating Vesicle Tethering
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	7 interacting genes: BARD1 PAXIP1 TMEM132D TRAPPC10 TRAPPC3L TRAPPC4 USP40
Entrez ID		55230	22878
HPRD ID		07166	10019
Ensembl ID		ENSG00000085982	ENSG00000153339
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	Q9Y2L5
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	TRAPP Complex TRAPPII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle Tethering Golgi Vesicle Transport Negative Regulation Of MRNA 3'-end Processing Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Regulation Of Cell Cycle G2/M Phase Transition Chorion Development Response To Ionizing Radiation BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Negative Regulation Of Protein Export From Nucleus Ubiquitin-modified Histone Reader Activity
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