SNW1 and IKZF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SNW1	IKZF1
Gene Name		SNW domain containing 1	IKAROS family zinc finger 1 (Ikaros)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spliceosomal Complex Positive Transcription Elongation Factor Complex B Nuclear Matrix Catalytic Step 2 Spliceosome SMAD3-SMAD4 Protein Complex	Nucleus Pericentric Heterochromatin Cytoplasm Protein Complex
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Poly(A) RNA Binding SMAD Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Positive Regulation Of Histone H3-K4 Methylation Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation Transcription, DNA-templated Cell Cycle Mesoderm Development Chromatin Modification B Cell Differentiation T Cell Differentiation Forebrain Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Thymus Development Peyer's Patch Development Positive Regulation Of NK T Cell Differentiation Retina Development In Camera-type Eye
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)	Acute lymphoblastic leukemia (childhood) ( 23512250 19684603 19684604) Crohn's disease ( 21102463) Hippocampal atrophy ( 19668339) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		58 interactors: ACTN2 ASCC2 CEP55 CIR1 CXorf56 DAXX EP300 GOLGA2 HDAC2 IKBKG IKZF1 JDP2 KRT40 LRP2BP LZTS2 MAGEA1 MAPK6 MEN1 MFAP1 MSL1 MTUS2 NCOR1 NCOR2 NHP2L1 NOTCH1 NOTCH3 NR0B1 NR0B2 PABPN1 PCBD2 PGR PPIL1 PRKAA2 RARA RB1 RBL1 RBL2 RBPJ RINT1 RXRA SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SRC TEX11 TFIP11 TNNT1 TOP1 TRAF1 TRIM15 TTC14 VAV2 VDR ZSCAN1	75 interactors: AEN ALKBH3 ANKRD11 AP1M1 AP2M1 ARMC7 BYSL C19orf66 C1orf109 C1orf174 C8orf33 CBX8 CDK2AP2 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CTBP2 DCX DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FRMD6 GLRX3 GMCL1P1 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LMO3 LSM4 MAD2L2 MCRS1 MORF4L1 MORF4L2 MTA1 NEK6 NOC4L NUDT21 PIN1 PNKP PRKAB2 PSMA1 PSMA4 RAD51D RBBP8 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SIN3A SIN3B SMARCA4 SNRPF SNW1 SPATC1L SYT17 TBP TDG UBE2I WTAP ZMAT2 ZNF417 ZNF581
Entrez ID		22938	10320
HPRD ID		04340	04318
Ensembl ID		ENSG00000100603	ENSG00000185811
Uniprot IDs		G3V3A4 Q13573	Q13422
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization Chromatin Modification Organ Development Regulation Of Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Signaling Regulation Of Binding Response To Transforming Growth Factor Beta Positive Regulation Of Metabolic Process Cell Cycle Chromosome Organization Negative Regulation Of Cell Differentiation	RNA Metabolic Process Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Organelle Organization Chromosome Organization Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Negative Regulation Of Gene Expression Histone Deacetylation Protein Deacetylation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Repair Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Metabolic Process Regulation Of Cell Cycle Phase Transition RNA Splicing
Tagcloud ?		buffer complicates consist demonstration deprotection ends exploit feasibility foci knock nucleoprotein pot1 pseudogene rap1 repetitive scaling shelterin shortening skiip telomere telomeres telomeric tif tin2 tpp1 trf1 trf2 ttaggg visualized	agree china cnki cochrane databases deletion derive efs eligible embase estimation ethnicity hazard infrastructure intervals lymphoblastic meta methodology precise pubmed random ratios science stratified subgroups unfavorable updated wanfang web
Tagcloud (Difference) ?		buffer complicates consist demonstration deprotection ends exploit feasibility foci knock nucleoprotein pot1 pseudogene rap1 repetitive scaling shelterin shortening skiip telomere telomeres telomeric tif tin2 tpp1 trf1 trf2 ttaggg visualized	agree china cnki cochrane databases deletion derive efs eligible embase estimation ethnicity hazard infrastructure intervals lymphoblastic meta methodology precise pubmed random ratios science stratified subgroups unfavorable updated wanfang web
Tagcloud (Intersection) ?